3DAU

Crystal structure of the ternary MTX NADPH complex of Escherichia coli dihydrofolate reductase

Summary for 3DAU

• Entry DOI: 10.2210/pdb3dau/pdb
• Related: 1RH3
• Descriptor: Dihydrofolate reductase, METHOTREXATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
• Functional Keywords: oxidoreductase, pseudo-rossmann fold, adenine nucleotide binding domain, antibiotic resistance, methotrexate resistance, nadp, one-carbon metabolism, trimethoprim resistance
• Biological source: Escherichia coli
• Total number of polymer chains: 1
• Total formula weight: 19219.20

Authors

Bennett, B.C.,Dealwis, C.G. (deposition date: 2008-05-30, release date: 2009-04-14, Last modification date: 2023-08-30)

• Primary citation: Bennett, B.C.,Wan, Q.,Ahmad, M.F.,Langan, P.,Dealwis, C.G.; X-ray structure of the ternary MTX.NADPH complex of the anthrax dihydrofolate reductase: a pharmacophore for dual-site inhibitor design.; J.Struct.Biol., 166:162-171, 2009; PubMed: 19374017

Experimental method

X-RAY DIFFRACTION (1.5 Å)