1RH3
DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (REDUCED FORM)
Summary for 1RH3
Entry DOI | 10.2210/pdb1rh3/pdb |
Descriptor | DIHYDROFOLATE REDUCTASE, METHOTREXATE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total) |
Functional Keywords | oxidoreductase, nadp, trimethoprim resistance, methotrexate resistance, one-carbon metabolism |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 19218.17 |
Authors | Sawaya, M.R.,Kraut, J. (deposition date: 1996-11-27, release date: 1997-03-12, Last modification date: 2023-08-09) |
Primary citation | Sawaya, M.R.,Kraut, J. Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. Biochemistry, 36:586-603, 1997 Cited by PubMed: 9012674DOI: 10.1021/bi962337c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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