5UIH

structure of DHFR with bound phenformin and NADP

Summary for 5UIH

Entry DOI	10.2210/pdb5uih/pdb
Related	5UII 5UIO 5UIP
Descriptor	Dihydrofolate reductase, N-(2-phenylethyl)imidodicarbonimidic diamide, SODIUM ION, ... (7 entities in total)
Functional Keywords	dhfr, phenformin, nadp, oxidoreductase
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	20188.28
Authors	Pedersen, L.C.,London, R.E. (deposition date: 2017-01-14, release date: 2017-11-22, Last modification date: 2023-10-04)
Primary citation	Gabel, S.A.,Duff, M.R.,Pedersen, L.C.,DeRose, E.F.,Krahn, J.M.,Howell, E.E.,London, R.E. A Structural Basis for Biguanide Activity. Biochemistry, 56:4786-4798, 2017 Cited by PubMed: 28766937 DOI: 10.1021/acs.biochem.7b00619 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.647 Å)

Structure validation