5CCC

wild-type E.coli dihydrofolate reductase complexed with 5,10-dideazatetrahydrofolate and oxidized nicotinamide adenine dinucleotide phosphate

Summary for 5CCC

Entry DOI	10.2210/pdb5ccc/pdb
Related	5CC9
Descriptor	Dihydrofolate reductase, 5,10-DIDEAZATETRAHYDROFOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
Functional Keywords	folate metabolism, oxidoreductase
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	19206.20
Authors	Oyen, D.,Wright, P.E. (deposition date: 2015-07-01, release date: 2015-08-05, Last modification date: 2023-09-27)
Primary citation	Oyen, D.,Fenwick, R.B.,Stanfield, R.L.,Dyson, H.J.,Wright, P.E. Cofactor-Mediated Conformational Dynamics Promote Product Release From Escherichia coli Dihydrofolate Reductase via an Allosteric Pathway. J.Am.Chem.Soc., 137:9459-9468, 2015 Cited by PubMed: 26147643 DOI: 10.1021/jacs.5b05707 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation