Binding of Nb113 camelid antibody fragment with the binary DHFR:folate complex

Summary for 4EJ1

Related4EIG 4EIZ
DescriptorDihydrofolate reductase, Nb113 camelid antibody fragment, FOLIC ACID, ... (5 entities in total)
Functional Keywordsfolate, oxidoreductase-immune system complex, oxidoreductase/immune system
Biological sourceEscherichia coli
Total number of polymer chains4
Total molecular weight67121.81
Oyen, D.,Srinivasan, V. (deposition date: 2012-04-06, release date: 2013-04-24, Last modification date: 2013-10-30)
Primary citation
Oyen, D.,Wechselberger, R.,Srinivasan, V.,Steyaert, J.,Barlow, J.N.
Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli.
Biochim.Biophys.Acta, 1834:2147-2157, 2013
PubMed: 23911607 (PDB entries with the same primary citation)
DOI: 10.1016/j.bbapap.2013.07.010
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.21830 1.7% 4.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-10-21