CA1698 camel antibody fragment in complex with DHFR

Summary for 4EIG

Related4EIZ 4EJ1
DescriptorDihydrofolate reductase, CA1698 camel antibody fragment (3 entities in total)
Functional Keywordsnadp binding, oxidoreductase-immune system complex, oxidoreductase/immune system
Biological sourceEscherichia coli
Total number of polymer chains2
Total molecular weight31644.59
Oyen, D.,Srinivasan, V. (deposition date: 2012-04-05, release date: 2013-04-24, Last modification date: 2017-11-15)
Primary citation
Oyen, D.,Wechselberger, R.,Srinivasan, V.,Steyaert, J.,Barlow, J.N.
Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli.
Biochim.Biophys.Acta, 1834:2147-2157, 2013
PubMed: 23911607 (PDB entries with the same primary citation)
DOI: 10.1016/j.bbapap.2013.07.010
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.210200.9%0.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report