7D4X

X-ray crystal Structure of E.coli Dihydrofolate Reductase complexed with folate and NADP+ at pH7.0

Summary for 7D4X

• Entry DOI: 10.2210/pdb7d4x/pdb
• Descriptor: Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
• Functional Keywords: dihydrofolate, reductase, alpha-beta sandiwitch, nadph, oxidoreductase
• Biological source: Escherichia coli (strain K12)
• Total number of polymer chains: 1
• Total formula weight: 19205.13

Authors

Wan, Q.,Dealwis, C. (deposition date: 2020-09-24, release date: 2021-06-09, Last modification date: 2023-11-29)

• Primary citation: Wan, Q.,Bennett, B.C.,Wymore, T.,Li, Z.,Wilson, M.A.,Brooks III, C.L.,Langan, P.,Kovalevsky, A.,Dealwis, C.G.; Capturing the Catalytic Proton of Dihydrofolate Reductase: Implications for General Acid-Base Catalysis; Acs Catalysis, 11:5873-5884, 2021; DOI: 10.1021/acscatal.1c00417

Experimental method

X-RAY DIFFRACTION (1.599 Å)