4DFR

CRYSTAL STRUCTURES OF ESCHERICHIA COLI AND LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE REFINED AT 1.7 ANGSTROMS RESOLUTION. I. GENERAL FEATURES AND BINDING OF METHOTREXATE

Replaces:  2DFR

Summary for 4DFR

DescriptorDIHYDROFOLATE REDUCTASE, CHLORIDE ION, METHOTREXATE, ... (5 entities in total)
Functional Keywordsoxido-reductase, oxidoreductase
Biological sourceEscherichia coli
Total number of polymer chains2
Total molecular weight37060.65
Authors
Filman, D.J.,Matthews, D.A.,Bolin, J.T.,Kraut, J. (deposition date: 1982-06-25, release date: 1982-10-21, Last modification date: 2017-11-29)
Primary citation
Bolin, J.T.,Filman, D.J.,Matthews, D.A.,Hamlin, R.C.,Kraut, J.
Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate.
J.Biol.Chem., 257:13650-13662, 1982
PubMed: 6815178 (PDB entries with the same primary citation)
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.7 Å)
NMR Information
?

Structure validation

ClashscoreRamachandran outliersSidechain outliers110.6%7.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4dfr
no rotation
Molmil generated image of 4dfr
rotated about x axis by 90°
Molmil generated image of 4dfr
rotated about y axis by 90°