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PDB: 41 件
4EAR
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BU of 4ear by Molmil
Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with DADMe-ImmG and phosphate
分子名称: 2-amino-7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, PHOSPHATE ION, Purine nucleoside phosphorylase
著者Haapalainen, A.M, Ho, M.C, Suarez, J.J, Almo, S.C, Schramm, V.L.
登録日2012-03-22
公開日2013-02-06
最終更新日2013-03-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Catalytic Site Conformations in Human PNP by (19)F-NMR and Crystallography.
Chem.Biol., 20, 2013
7ZSL
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BU of 7zsl by Molmil
human purine nucleoside phosphorylase in complex with JS-196
分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Purine nucleoside phosphorylase, ...
著者Djukic, S, Pachl, P, Rezacova, P.
登録日2022-05-07
公開日2023-05-17
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors.
J.Med.Chem., 66, 2023
7ZSO
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BU of 7zso by Molmil
human purine nucleoside phosphorylase in complex with JS-554
分子名称: GLYCEROL, Purine nucleoside phosphorylase, SODIUM ION, ...
著者Djukic, S, Pachl, P, Rezacova, P.
登録日2022-05-07
公開日2023-05-17
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors.
J.Med.Chem., 66, 2023
3BGS
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BU of 3bgs by Molmil
Structure of human purine nucleoside phosphorylase with L-DADMe-ImmH and phosphate
分子名称: 7-[[(3R,4R)-3-(hydroxymethyl)-4-oxidanyl-pyrrolidin-1-ium-1-yl]methyl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one, PHOSPHATE ION, purine nucleoside phosphorylase
著者Murkin, A.S, Ramagopal, U.A, Almo, S.C, Schramm, V.L.
登録日2007-11-27
公開日2008-01-08
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.099 Å)
主引用文献L-Enantiomers of transition state analogue inhibitors bound to human purine nucleoside phosphorylase
J.Am.Chem.Soc., 130, 2008
4GKA
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BU of 4gka by Molmil
Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with phosphate
分子名称: GLYCEROL, PHOSPHATE ION, Purine nucleoside phosphorylase
著者Haapalainen, A.M, Ho, M.C, Suarez, J.J, Almo, S.C, Schramm, V.L.
登録日2012-08-10
公開日2013-02-06
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Catalytic Site Conformations in Human PNP by (19)F-NMR and Crystallography.
Chem.Biol., 20, 2013
5UGF
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BU of 5ugf by Molmil
Crystal structure of human purine nucleoside phosphorylase (F159Y) mutant complexed with DADMe-ImmG and phosphate
分子名称: 2-amino-7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, PHOSPHATE ION, Purine nucleoside phosphorylase
著者Harijan, R.K, Cameron, S.A, Bonanno, J.B, Almo, S.C, Schramm, V.L.
登録日2017-01-08
公開日2017-06-21
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Catalytic-site design for inverse heavy-enzyme isotope effects in human purine nucleoside phosphorylase.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
1RSZ
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BU of 1rsz by Molmil
Structure of human purine nucleoside phosphorylase in complex with DADMe-Immucillin-H and sulfate
分子名称: 7-[[(3R,4R)-3-(hydroxymethyl)-4-oxidanyl-pyrrolidin-1-ium-1-yl]methyl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one, Purine nucleoside phosphorylase, SULFATE ION
著者Shi, W, Lewandowicz, A, Tyler, P.C, Furneaux, R.H, Almo, S.C, Schramm, V.L.
登録日2003-12-10
公開日2005-02-22
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural comparison of human and malarial purine nucleoside phosphorylases
To be Published
2A0Y
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BU of 2a0y by Molmil
Structure of human purine nucleoside phosphorylase H257D mutant
分子名称: 7-[[(3R,4R)-3-(hydroxymethyl)-4-oxidanyl-pyrrolidin-1-ium-1-yl]methyl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one, Purine nucleoside phosphorylase, SULFATE ION
著者Murkin, A.S, Shi, W, Schramm, V.L.
登録日2005-06-17
公開日2006-06-06
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Neighboring group participation in the transition state of human purine nucleoside phosphorylase.
Biochemistry, 46, 2007
2A0W
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BU of 2a0w by Molmil
Structure of human purine nucleoside phosphorylase H257G mutant
分子名称: 7-[[(3R,4R)-3-(hydroxymethyl)-4-oxidanyl-pyrrolidin-1-ium-1-yl]methyl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one, Purine nucleoside phosphorylase, SULFATE ION
著者Murkin, A.S, Shi, W, Schramm, V.L.
登録日2005-06-17
公開日2006-06-06
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Neighboring group participation in the transition state of human purine nucleoside phosphorylase.
Biochemistry, 46, 2007
2A0X
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BU of 2a0x by Molmil
Structure of human purine nucleoside phosphorylase H257F mutant
分子名称: 7-[[(3R,4R)-3-(hydroxymethyl)-4-oxidanyl-pyrrolidin-1-ium-1-yl]methyl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one, Purine nucleoside phosphorylase, SULFATE ION
著者Murkin, A.S, Shi, W, Schramm, V.L.
登録日2005-06-17
公開日2006-06-06
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Neighboring group participation in the transition state of human purine nucleoside phosphorylase.
Biochemistry, 46, 2007
7ZSP
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BU of 7zsp by Molmil
human purine nucleoside phosphorylase in complex with JS-555
分子名称: 6-tungstotellurate(VI), Purine nucleoside phosphorylase, SODIUM ION, ...
著者Djukic, S, Pachl, P, Rezacova, P.
登録日2022-05-08
公開日2023-05-17
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors.
J.Med.Chem., 66, 2023
5ETJ
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BU of 5etj by Molmil
Crystal structure of purine nucleoside phosphorylase (E258D, L261A) mutant from human complexed with DADMe-ImmG and phosphate
分子名称: 2-amino-7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, PHOSPHATE ION, Purine nucleoside phosphorylase
著者Cameron, S.A, Suarez, J, Schramm, V.L, Almo, S.C.
登録日2015-11-17
公開日2016-09-14
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Modulating Enzyme Catalysis through Mutations Designed to Alter Rapid Protein Dynamics.
J.Am.Chem.Soc., 138, 2016
3PHB
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BU of 3phb by Molmil
Crystal Structure of human purine nucleoside phosphorylase in complex with DADMe-ImmG
分子名称: 2-amino-7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, PHOSPHATE ION, Purine nucleoside phosphorylase
著者Ho, M, Cassera, M.B, Murkin, A.S, Almo, S.C, Schramm, V.L.
登録日2010-11-03
公開日2011-11-09
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal Structure of human purine nucleoside phosphorylase in complex with DADMe-ImmG
to be published
1RT9
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BU of 1rt9 by Molmil
Structure of human purine nucleoside phosphorylase in complex with Immucillin-H and sulfate
分子名称: 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL, Purine nucleoside phosphorylase, SULFATE ION
著者Shi, W, Lewandowicz, A, Tyler, P.C, Furneaux, R.H, Almo, S.C, Schramm, V.L.
登録日2003-12-10
公開日2005-02-22
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural comparison of human and malarial purine nucleoside phosphorylases
To be Published
4EB8
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BU of 4eb8 by Molmil
Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with DADMe-ImmG and phosphate
分子名称: 1,2-ETHANEDIOL, 2-amino-7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, PHOSPHATE ION, ...
著者Ho, M.C, Haapalainen, A.M, Suarez, J.J, Almo, S.C, Schramm, V.L.
登録日2012-03-23
公開日2013-02-06
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Catalytic Site Conformations in Human PNP by (19)F-NMR and Crystallography.
Chem.Biol., 20, 2013
3GB9
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BU of 3gb9 by Molmil
Human purine nucleoside phosphorylase double mutant E201Q,N243D complexed with 2-fluoroadenine
分子名称: 2-fluoroadenine, GLYCEROL, Purine nucleoside phosphorylase, ...
著者Sawaya, M.R, Afshar, S.
登録日2009-02-19
公開日2009-04-14
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure of a mutant human purine nucleoside phosphorylase with the prodrug, 2-fluoro-2'-deoxyadenosine and the cytotoxic drug, 2-fluoroadenine.
Protein Sci., 18, 2009
1M73
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BU of 1m73 by Molmil
CRYSTAL STRUCTURE OF HUMAN PNP AT 2.3A RESOLUTION
分子名称: PURINE NUCLEOSIDE PHOSPHORYLASE, SULFATE ION
著者De Azevedo Jr, W.F, Marangoni Dos Santos, D, Canduri, F, Santos, G.C, Olivieri, J.R, Silva, R.G, Basso, L.A, Palma, M.S, Santos, D.S.
登録日2002-07-18
公開日2003-09-16
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of human purine nucleoside phosphorylase at 2.3A resolution.
Biochem.Biophys.Res.Commun., 308, 2003
7ZSN
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BU of 7zsn by Molmil
human purine nucleoside phosphorylase in complex with JS-379
分子名称: 6-tungstotellurate(VI), Purine nucleoside phosphorylase, SULFATE ION, ...
著者Djukic, S, Pachl, P, Rezacova, P.
登録日2022-05-07
公開日2023-05-17
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.36 Å)
主引用文献Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors.
J.Med.Chem., 66, 2023
3K8O
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BU of 3k8o by Molmil
Crystal structure of human purine nucleoside phosphorylase in complex with DATMe-ImmH
分子名称: 7-({[(1R,2S)-2,3-DIHYDROXY-1-(HYDROXYMETHYL)PROPYL]AMINO}METHYL)-3,5-DIHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONE, Purine nucleoside phosphorylase, SULFATE ION
著者Ho, M, Rinaldo-matthis, A, Almo, S.C, Schramm, V.L.
登録日2009-10-14
公開日2010-03-02
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of human purine nucleoside phosphorylase in complex with DATMe-Immucillin H
Proc.Natl.Acad.Sci.USA, 2010
3K8Q
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BU of 3k8q by Molmil
Crystal structure of human purine nucleoside phosphorylase in complex with SerMe-Immucillin H
分子名称: 7-({[2-hydroxy-1-(hydroxymethyl)ethyl]amino}methyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, PHOSPHATE ION, Purine nucleoside phosphorylase
著者Ho, M, Almo, S.C, Scharmm, V.L.
登録日2009-10-14
公開日2010-03-02
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of human nucleoside phosphorylase in complex with SerMe-ImmH
Proc.Natl.Acad.Sci.USA, 2010
1RR6
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BU of 1rr6 by Molmil
Structure of human purine nucleoside phosphorylase in complex with Immucillin-H and phosphate
分子名称: 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL, PHOSPHATE ION, Purine nucleoside phosphorylase
著者Shi, W, Lewandowicz, A, Tyler, P.C, Furneaux, R.H, Almo, S.C, Schramm, V.L.
登録日2003-12-08
公開日2005-02-22
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Plasmodium falciparum purine nucleoside phosphorylase: crystal structures, immucillin inhibitors, and dual catalytic function.
J.Biol.Chem., 279, 2004
2ON6
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BU of 2on6 by Molmil
Crystal structure of human purine nucleoside phosphorylase mutant H257F with Imm-H
分子名称: 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL, Purine nucleoside phosphorylase
著者Rinaldo-Matthis, A, Murkin, A.S, Almo, S.C, Schramm, V.L.
登録日2007-01-23
公開日2007-05-22
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.503 Å)
主引用文献Neighboring Group Participation in the Transition State of Human Purine Nucleoside Phosphorylase
Biochemistry, 46, 2007
3GGS
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BU of 3ggs by Molmil
Human purine nucleoside phosphorylase double mutant E201Q,N243D complexed with 2-fluoro-2'-deoxyadenosine
分子名称: 5-(6-AMINO-2-FLUORO-PURIN-9-YL)-2-HYDROXYMETHYL-TETRAHYDRO-FURAN-3-OL, Purine nucleoside phosphorylase, SULFATE ION
著者Sawaya, M.R, Afshar, S.
登録日2009-03-02
公開日2009-04-14
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.52 Å)
主引用文献Structure of a mutant human purine nucleoside phosphorylase with the prodrug, 2-fluoro-2'-deoxyadenosine and the cytotoxic drug, 2-fluoroadenine.
Protein Sci., 18, 2009
2OC9
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BU of 2oc9 by Molmil
Crystal structure of human purine nucleoside phosphorylase mutant H257G with Imm-H
分子名称: 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL, PHOSPHATE ION, Purine nucleoside phosphorylase
著者Rinaldo-Matthis, A, Almo, S.C, Schramm, V.L.
登録日2006-12-20
公開日2007-05-22
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Neighboring Group Participation in the Transition State of Human Purine Nucleoside Phosphorylase
Biochemistry, 46, 2007
2OC4
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Crystal structure of human purine nucleoside phosphorylase mutant H257D with Imm-H
分子名称: 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL, PHOSPHATE ION, Purine nucleoside phosphorylase
著者Rinaldo-Matthis, A, Almo, S.C, Schramm, V.L.
登録日2006-12-20
公開日2007-05-22
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.592 Å)
主引用文献Neighboring Group Participation in the Transition State of Human Purine Nucleoside Phosphorylase
Biochemistry, 46, 2007

 

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