5UGF

Crystal structure of human purine nucleoside phosphorylase (F159Y) mutant complexed with DADMe-ImmG and phosphate

Summary for 5UGF

Entry DOI	10.2210/pdb5ugf/pdb
Descriptor	Purine nucleoside phosphorylase, PHOSPHATE ION, 2-amino-7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, ... (4 entities in total)
Functional Keywords	phosphorylase, inhibitor, transition state analogue, purine salvage pathway, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	6
Total formula weight	218819.84
Authors	Harijan, R.K.,Cameron, S.A.,Bonanno, J.B.,Almo, S.C.,Schramm, V.L. (deposition date: 2017-01-08, release date: 2017-06-21, Last modification date: 2023-10-04)
Primary citation	Harijan, R.K.,Zoi, I.,Antoniou, D.,Schwartz, S.D.,Schramm, V.L. Catalytic-site design for inverse heavy-enzyme isotope effects in human purine nucleoside phosphorylase. Proc. Natl. Acad. Sci. U.S.A., 114:6456-6461, 2017 Cited by PubMed: 28584087 DOI: 10.1073/pnas.1704786114 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation