3GB9
Human purine nucleoside phosphorylase double mutant E201Q,N243D complexed with 2-fluoroadenine
Summary for 3GB9
Entry DOI | 10.2210/pdb3gb9/pdb |
Descriptor | Purine nucleoside phosphorylase, 2-fluoroadenine, SULFATE ION, ... (5 entities in total) |
Functional Keywords | enzyme-product complex, disease mutation, glycosyltransferase, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm, cytoskeleton : P00491 |
Total number of polymer chains | 3 |
Total formula weight | 106922.26 |
Authors | Sawaya, M.R.,Afshar, S. (deposition date: 2009-02-19, release date: 2009-04-14, Last modification date: 2023-09-06) |
Primary citation | Afshar, S.,Sawaya, M.R.,Morrison, S.L. Structure of a mutant human purine nucleoside phosphorylase with the prodrug, 2-fluoro-2'-deoxyadenosine and the cytotoxic drug, 2-fluoroadenine. Protein Sci., 18:1107-1114, 2009 Cited by PubMed: 19388075DOI: 10.1002/pro.91 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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