5ETJ

Crystal structure of purine nucleoside phosphorylase (E258D, L261A) mutant from human complexed with DADMe-ImmG and phosphate

Summary for 5ETJ

Entry DOI	10.2210/pdb5etj/pdb
Related	3PHB
Descriptor	Purine nucleoside phosphorylase, 2-amino-7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, PHOSPHATE ION, ... (4 entities in total)
Functional Keywords	phosphorylase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	6
Total formula weight	219367.79
Authors	Cameron, S.A.,Suarez, J.,Schramm, V.L.,Almo, S.C. (deposition date: 2015-11-17, release date: 2016-09-14, Last modification date: 2023-09-27)
Primary citation	Zoi, I.,Suarez, J.,Antoniou, D.,Cameron, S.A.,Schramm, V.L.,Schwartz, S.D. Modulating Enzyme Catalysis through Mutations Designed to Alter Rapid Protein Dynamics. J.Am.Chem.Soc., 138:3403-3409, 2016 Cited by PubMed: 26927977 DOI: 10.1021/jacs.5b12551 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation