5ETJ
Crystal structure of purine nucleoside phosphorylase (E258D, L261A) mutant from human complexed with DADMe-ImmG and phosphate
Summary for 5ETJ
Entry DOI | 10.2210/pdb5etj/pdb |
Related | 3PHB |
Descriptor | Purine nucleoside phosphorylase, 2-amino-7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | phosphorylase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 6 |
Total formula weight | 219367.79 |
Authors | Cameron, S.A.,Suarez, J.,Schramm, V.L.,Almo, S.C. (deposition date: 2015-11-17, release date: 2016-09-14, Last modification date: 2023-09-27) |
Primary citation | Zoi, I.,Suarez, J.,Antoniou, D.,Cameron, S.A.,Schramm, V.L.,Schwartz, S.D. Modulating Enzyme Catalysis through Mutations Designed to Alter Rapid Protein Dynamics. J.Am.Chem.Soc., 138:3403-3409, 2016 Cited by PubMed: 26927977DOI: 10.1021/jacs.5b12551 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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