5ETJ
Crystal structure of purine nucleoside phosphorylase (E258D, L261A) mutant from human complexed with DADMe-ImmG and phosphate
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000255 | biological_process | allantoin metabolic process |
A | 0001882 | molecular_function | nucleoside binding |
A | 0002060 | molecular_function | purine nucleobase binding |
A | 0003824 | molecular_function | catalytic activity |
A | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005576 | cellular_component | extracellular region |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
A | 0006148 | biological_process | inosine catabolic process |
A | 0006149 | biological_process | deoxyinosine catabolic process |
A | 0006157 | biological_process | deoxyadenosine catabolic process |
A | 0006166 | biological_process | purine ribonucleoside salvage |
A | 0006204 | biological_process | IMP catabolic process |
A | 0006738 | biological_process | nicotinamide riboside catabolic process |
A | 0006955 | biological_process | immune response |
A | 0009116 | biological_process | nucleoside metabolic process |
A | 0009165 | biological_process | nucleotide biosynthetic process |
A | 0009410 | biological_process | response to xenobiotic stimulus |
A | 0016757 | molecular_function | glycosyltransferase activity |
A | 0016763 | molecular_function | pentosyltransferase activity |
A | 0032743 | biological_process | positive regulation of interleukin-2 production |
A | 0034418 | biological_process | urate biosynthetic process |
A | 0034774 | cellular_component | secretory granule lumen |
A | 0042102 | biological_process | positive regulation of T cell proliferation |
A | 0042301 | molecular_function | phosphate ion binding |
A | 0042802 | molecular_function | identical protein binding |
A | 0043101 | biological_process | purine-containing compound salvage |
A | 0046059 | biological_process | dAMP catabolic process |
A | 0046638 | biological_process | positive regulation of alpha-beta T cell differentiation |
A | 0047975 | molecular_function | guanosine phosphorylase activity |
A | 0070062 | cellular_component | extracellular exosome |
A | 1904813 | cellular_component | ficolin-1-rich granule lumen |
B | 0000255 | biological_process | allantoin metabolic process |
B | 0001882 | molecular_function | nucleoside binding |
B | 0002060 | molecular_function | purine nucleobase binding |
B | 0003824 | molecular_function | catalytic activity |
B | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005576 | cellular_component | extracellular region |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006139 | biological_process | nucleobase-containing compound metabolic process |
B | 0006148 | biological_process | inosine catabolic process |
B | 0006149 | biological_process | deoxyinosine catabolic process |
B | 0006157 | biological_process | deoxyadenosine catabolic process |
B | 0006166 | biological_process | purine ribonucleoside salvage |
B | 0006204 | biological_process | IMP catabolic process |
B | 0006738 | biological_process | nicotinamide riboside catabolic process |
B | 0006955 | biological_process | immune response |
B | 0009116 | biological_process | nucleoside metabolic process |
B | 0009165 | biological_process | nucleotide biosynthetic process |
B | 0009410 | biological_process | response to xenobiotic stimulus |
B | 0016757 | molecular_function | glycosyltransferase activity |
B | 0016763 | molecular_function | pentosyltransferase activity |
B | 0032743 | biological_process | positive regulation of interleukin-2 production |
B | 0034418 | biological_process | urate biosynthetic process |
B | 0034774 | cellular_component | secretory granule lumen |
B | 0042102 | biological_process | positive regulation of T cell proliferation |
B | 0042301 | molecular_function | phosphate ion binding |
B | 0042802 | molecular_function | identical protein binding |
B | 0043101 | biological_process | purine-containing compound salvage |
B | 0046059 | biological_process | dAMP catabolic process |
B | 0046638 | biological_process | positive regulation of alpha-beta T cell differentiation |
B | 0047975 | molecular_function | guanosine phosphorylase activity |
B | 0070062 | cellular_component | extracellular exosome |
B | 1904813 | cellular_component | ficolin-1-rich granule lumen |
C | 0000255 | biological_process | allantoin metabolic process |
C | 0001882 | molecular_function | nucleoside binding |
C | 0002060 | molecular_function | purine nucleobase binding |
C | 0003824 | molecular_function | catalytic activity |
C | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
C | 0005515 | molecular_function | protein binding |
C | 0005576 | cellular_component | extracellular region |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0006139 | biological_process | nucleobase-containing compound metabolic process |
C | 0006148 | biological_process | inosine catabolic process |
C | 0006149 | biological_process | deoxyinosine catabolic process |
C | 0006157 | biological_process | deoxyadenosine catabolic process |
C | 0006166 | biological_process | purine ribonucleoside salvage |
C | 0006204 | biological_process | IMP catabolic process |
C | 0006738 | biological_process | nicotinamide riboside catabolic process |
C | 0006955 | biological_process | immune response |
C | 0009116 | biological_process | nucleoside metabolic process |
C | 0009165 | biological_process | nucleotide biosynthetic process |
C | 0009410 | biological_process | response to xenobiotic stimulus |
C | 0016757 | molecular_function | glycosyltransferase activity |
C | 0016763 | molecular_function | pentosyltransferase activity |
C | 0032743 | biological_process | positive regulation of interleukin-2 production |
C | 0034418 | biological_process | urate biosynthetic process |
C | 0034774 | cellular_component | secretory granule lumen |
C | 0042102 | biological_process | positive regulation of T cell proliferation |
C | 0042301 | molecular_function | phosphate ion binding |
C | 0042802 | molecular_function | identical protein binding |
C | 0043101 | biological_process | purine-containing compound salvage |
C | 0046059 | biological_process | dAMP catabolic process |
C | 0046638 | biological_process | positive regulation of alpha-beta T cell differentiation |
C | 0047975 | molecular_function | guanosine phosphorylase activity |
C | 0070062 | cellular_component | extracellular exosome |
C | 1904813 | cellular_component | ficolin-1-rich granule lumen |
D | 0000255 | biological_process | allantoin metabolic process |
D | 0001882 | molecular_function | nucleoside binding |
D | 0002060 | molecular_function | purine nucleobase binding |
D | 0003824 | molecular_function | catalytic activity |
D | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
D | 0005515 | molecular_function | protein binding |
D | 0005576 | cellular_component | extracellular region |
D | 0005737 | cellular_component | cytoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0006139 | biological_process | nucleobase-containing compound metabolic process |
D | 0006148 | biological_process | inosine catabolic process |
D | 0006149 | biological_process | deoxyinosine catabolic process |
D | 0006157 | biological_process | deoxyadenosine catabolic process |
D | 0006166 | biological_process | purine ribonucleoside salvage |
D | 0006204 | biological_process | IMP catabolic process |
D | 0006738 | biological_process | nicotinamide riboside catabolic process |
D | 0006955 | biological_process | immune response |
D | 0009116 | biological_process | nucleoside metabolic process |
D | 0009165 | biological_process | nucleotide biosynthetic process |
D | 0009410 | biological_process | response to xenobiotic stimulus |
D | 0016757 | molecular_function | glycosyltransferase activity |
D | 0016763 | molecular_function | pentosyltransferase activity |
D | 0032743 | biological_process | positive regulation of interleukin-2 production |
D | 0034418 | biological_process | urate biosynthetic process |
D | 0034774 | cellular_component | secretory granule lumen |
D | 0042102 | biological_process | positive regulation of T cell proliferation |
D | 0042301 | molecular_function | phosphate ion binding |
D | 0042802 | molecular_function | identical protein binding |
D | 0043101 | biological_process | purine-containing compound salvage |
D | 0046059 | biological_process | dAMP catabolic process |
D | 0046638 | biological_process | positive regulation of alpha-beta T cell differentiation |
D | 0047975 | molecular_function | guanosine phosphorylase activity |
D | 0070062 | cellular_component | extracellular exosome |
D | 1904813 | cellular_component | ficolin-1-rich granule lumen |
E | 0000255 | biological_process | allantoin metabolic process |
E | 0001882 | molecular_function | nucleoside binding |
E | 0002060 | molecular_function | purine nucleobase binding |
E | 0003824 | molecular_function | catalytic activity |
E | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
E | 0005515 | molecular_function | protein binding |
E | 0005576 | cellular_component | extracellular region |
E | 0005737 | cellular_component | cytoplasm |
E | 0005829 | cellular_component | cytosol |
E | 0006139 | biological_process | nucleobase-containing compound metabolic process |
E | 0006148 | biological_process | inosine catabolic process |
E | 0006149 | biological_process | deoxyinosine catabolic process |
E | 0006157 | biological_process | deoxyadenosine catabolic process |
E | 0006166 | biological_process | purine ribonucleoside salvage |
E | 0006204 | biological_process | IMP catabolic process |
E | 0006738 | biological_process | nicotinamide riboside catabolic process |
E | 0006955 | biological_process | immune response |
E | 0009116 | biological_process | nucleoside metabolic process |
E | 0009165 | biological_process | nucleotide biosynthetic process |
E | 0009410 | biological_process | response to xenobiotic stimulus |
E | 0016757 | molecular_function | glycosyltransferase activity |
E | 0016763 | molecular_function | pentosyltransferase activity |
E | 0032743 | biological_process | positive regulation of interleukin-2 production |
E | 0034418 | biological_process | urate biosynthetic process |
E | 0034774 | cellular_component | secretory granule lumen |
E | 0042102 | biological_process | positive regulation of T cell proliferation |
E | 0042301 | molecular_function | phosphate ion binding |
E | 0042802 | molecular_function | identical protein binding |
E | 0043101 | biological_process | purine-containing compound salvage |
E | 0046059 | biological_process | dAMP catabolic process |
E | 0046638 | biological_process | positive regulation of alpha-beta T cell differentiation |
E | 0047975 | molecular_function | guanosine phosphorylase activity |
E | 0070062 | cellular_component | extracellular exosome |
E | 1904813 | cellular_component | ficolin-1-rich granule lumen |
F | 0000255 | biological_process | allantoin metabolic process |
F | 0001882 | molecular_function | nucleoside binding |
F | 0002060 | molecular_function | purine nucleobase binding |
F | 0003824 | molecular_function | catalytic activity |
F | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
F | 0005515 | molecular_function | protein binding |
F | 0005576 | cellular_component | extracellular region |
F | 0005737 | cellular_component | cytoplasm |
F | 0005829 | cellular_component | cytosol |
F | 0006139 | biological_process | nucleobase-containing compound metabolic process |
F | 0006148 | biological_process | inosine catabolic process |
F | 0006149 | biological_process | deoxyinosine catabolic process |
F | 0006157 | biological_process | deoxyadenosine catabolic process |
F | 0006166 | biological_process | purine ribonucleoside salvage |
F | 0006204 | biological_process | IMP catabolic process |
F | 0006738 | biological_process | nicotinamide riboside catabolic process |
F | 0006955 | biological_process | immune response |
F | 0009116 | biological_process | nucleoside metabolic process |
F | 0009165 | biological_process | nucleotide biosynthetic process |
F | 0009410 | biological_process | response to xenobiotic stimulus |
F | 0016757 | molecular_function | glycosyltransferase activity |
F | 0016763 | molecular_function | pentosyltransferase activity |
F | 0032743 | biological_process | positive regulation of interleukin-2 production |
F | 0034418 | biological_process | urate biosynthetic process |
F | 0034774 | cellular_component | secretory granule lumen |
F | 0042102 | biological_process | positive regulation of T cell proliferation |
F | 0042301 | molecular_function | phosphate ion binding |
F | 0042802 | molecular_function | identical protein binding |
F | 0043101 | biological_process | purine-containing compound salvage |
F | 0046059 | biological_process | dAMP catabolic process |
F | 0046638 | biological_process | positive regulation of alpha-beta T cell differentiation |
F | 0047975 | molecular_function | guanosine phosphorylase activity |
F | 0070062 | cellular_component | extracellular exosome |
F | 1904813 | cellular_component | ficolin-1-rich granule lumen |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 17 |
Details | binding site for residue IM5 A 301 |
Chain | Residue |
A | SER33 |
A | GLY218 |
A | MET219 |
A | THR242 |
A | ASN243 |
A | HIS257 |
A | PO4302 |
A | HOH412 |
B | PHE159 |
A | HIS86 |
A | TYR88 |
A | ALA116 |
A | GLY118 |
A | VAL195 |
A | PHE200 |
A | GLU201 |
A | VAL217 |
site_id | AC2 |
Number of Residues | 10 |
Details | binding site for residue PO4 A 302 |
Chain | Residue |
A | GLY32 |
A | SER33 |
A | HIS64 |
A | ARG84 |
A | HIS86 |
A | ASN115 |
A | ALA116 |
A | SER220 |
A | IM5301 |
A | HOH403 |
site_id | AC3 |
Number of Residues | 6 |
Details | binding site for residue PO4 A 303 |
Chain | Residue |
A | MET1 |
A | ARG148 |
C | MET1 |
C | PRO92 |
C | GLN144 |
C | HOH425 |
site_id | AC4 |
Number of Residues | 18 |
Details | binding site for residue IM5 B 301 |
Chain | Residue |
B | HIS86 |
B | TYR88 |
B | ALA116 |
B | ALA117 |
B | GLY118 |
B | VAL195 |
B | PHE200 |
B | GLU201 |
B | VAL217 |
B | GLY218 |
B | MET219 |
B | THR242 |
B | ASN243 |
B | HIS257 |
B | VAL260 |
B | PO4302 |
B | HOH438 |
C | PHE159 |
site_id | AC5 |
Number of Residues | 10 |
Details | binding site for residue PO4 B 302 |
Chain | Residue |
B | GLY32 |
B | SER33 |
B | HIS64 |
B | ARG84 |
B | HIS86 |
B | ASN115 |
B | ALA116 |
B | SER220 |
B | IM5301 |
B | HOH401 |
site_id | AC6 |
Number of Residues | 5 |
Details | binding site for residue PO4 B 303 |
Chain | Residue |
A | PRO92 |
A | GLN144 |
A | HOH427 |
B | MET1 |
B | ARG148 |
site_id | AC7 |
Number of Residues | 18 |
Details | binding site for residue IM5 C 301 |
Chain | Residue |
A | PHE159 |
C | SER33 |
C | HIS86 |
C | TYR88 |
C | ALA116 |
C | GLY118 |
C | VAL195 |
C | PHE200 |
C | GLU201 |
C | VAL217 |
C | GLY218 |
C | MET219 |
C | THR242 |
C | ASN243 |
C | HIS257 |
C | VAL260 |
C | PO4302 |
C | HOH410 |
site_id | AC8 |
Number of Residues | 10 |
Details | binding site for residue PO4 C 302 |
Chain | Residue |
C | GLY32 |
C | SER33 |
C | HIS64 |
C | ARG84 |
C | HIS86 |
C | ASN115 |
C | ALA116 |
C | SER220 |
C | IM5301 |
C | HOH402 |
site_id | AC9 |
Number of Residues | 5 |
Details | binding site for residue PO4 C 303 |
Chain | Residue |
B | PRO92 |
B | GLN144 |
C | MET1 |
C | ARG148 |
C | HOH419 |
site_id | AD1 |
Number of Residues | 17 |
Details | binding site for residue IM5 D 301 |
Chain | Residue |
D | SER33 |
D | HIS86 |
D | TYR88 |
D | ALA116 |
D | GLY118 |
D | VAL195 |
D | PHE200 |
D | GLU201 |
D | VAL217 |
D | GLY218 |
D | MET219 |
D | THR242 |
D | ASN243 |
D | HIS257 |
D | VAL260 |
D | PO4302 |
D | HOH414 |
site_id | AD2 |
Number of Residues | 10 |
Details | binding site for residue PO4 D 302 |
Chain | Residue |
D | GLY32 |
D | SER33 |
D | HIS64 |
D | ARG84 |
D | HIS86 |
D | ASN115 |
D | ALA116 |
D | SER220 |
D | IM5301 |
D | HOH405 |
site_id | AD3 |
Number of Residues | 4 |
Details | binding site for residue PO4 D 303 |
Chain | Residue |
D | MET1 |
D | ARG148 |
E | PRO92 |
E | GLN144 |
site_id | AD4 |
Number of Residues | 18 |
Details | binding site for residue IM5 E 301 |
Chain | Residue |
D | PHE159 |
E | SER33 |
E | HIS86 |
E | TYR88 |
E | ALA116 |
E | GLY118 |
E | VAL195 |
E | PHE200 |
E | GLU201 |
E | VAL217 |
E | GLY218 |
E | MET219 |
E | THR242 |
E | ASN243 |
E | HIS257 |
E | VAL260 |
E | PO4302 |
E | HOH405 |
site_id | AD5 |
Number of Residues | 10 |
Details | binding site for residue PO4 E 302 |
Chain | Residue |
E | GLY32 |
E | SER33 |
E | HIS64 |
E | ARG84 |
E | HIS86 |
E | ASN115 |
E | ALA116 |
E | SER220 |
E | IM5301 |
E | HOH403 |
site_id | AD6 |
Number of Residues | 6 |
Details | binding site for residue PO4 F 301 |
Chain | Residue |
E | MET1 |
E | ARG148 |
F | PRO92 |
F | GLN144 |
F | HOH412 |
F | HOH443 |
site_id | AD7 |
Number of Residues | 14 |
Details | binding site for residue IM5 F 302 |
Chain | Residue |
E | PHE159 |
F | TYR88 |
F | ALA116 |
F | GLY118 |
F | VAL195 |
F | PHE200 |
F | GLU201 |
F | GLY218 |
F | MET219 |
F | THR242 |
F | ASN243 |
F | HIS257 |
F | PO4303 |
F | HOH419 |
site_id | AD8 |
Number of Residues | 10 |
Details | binding site for residue PO4 F 303 |
Chain | Residue |
F | GLY32 |
F | SER33 |
F | HIS64 |
F | ARG84 |
F | HIS86 |
F | ASN115 |
F | ALA116 |
F | SER220 |
F | IM5302 |
F | HOH401 |
site_id | AD9 |
Number of Residues | 6 |
Details | binding site for residue PO4 F 304 |
Chain | Residue |
D | MET1 |
D | PRO92 |
D | GLN144 |
D | HOH406 |
F | MET1 |
F | ARG148 |
Functional Information from PROSITE/UniProt
site_id | PS01240 |
Number of Residues | 42 |
Details | PNP_MTAP_2 Purine and other phosphorylases family 2 signature. VmmqGrfHmYegypLwkvTfpVrVfhllGvdt.LVvtNAaGGL |
Chain | Residue | Details |
A | VAL79-LEU120 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:23438750, ECO:0000305|PubMed:14706628, ECO:0000305|PubMed:1763067, ECO:0007744|PDB:1RCT, ECO:0007744|PDB:1ULA, ECO:0007744|PDB:1ULB, ECO:0007744|PDB:4EAR, ECO:0007744|PDB:4EB8, ECO:0007744|PDB:4GKA |
Chain | Residue | Details |
A | SER33 | |
B | SER33 | |
C | SER33 | |
D | SER33 | |
E | SER33 | |
F | SER33 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P55859 |
Chain | Residue | Details |
A | HIS64 | |
B | HIS64 | |
C | HIS64 | |
D | HIS64 | |
E | HIS64 | |
F | HIS64 |
site_id | SWS_FT_FI3 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:23438750, ECO:0000305|PubMed:14706628, ECO:0000305|PubMed:1763067, ECO:0007744|PDB:1RCT, ECO:0007744|PDB:1ULA, ECO:0007744|PDB:1ULB, ECO:0007744|PDB:1V3Q, ECO:0007744|PDB:4EAR, ECO:0007744|PDB:4EB8, ECO:0007744|PDB:4GKA |
Chain | Residue | Details |
A | ARG84 | |
B | ARG84 | |
C | ARG84 | |
D | ARG84 | |
E | ARG84 | |
F | ARG84 |
site_id | SWS_FT_FI4 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:14706628, ECO:0000269|PubMed:23438750, ECO:0007744|PDB:1RCT, ECO:0007744|PDB:4EAR, ECO:0007744|PDB:4EB8 |
Chain | Residue | Details |
A | TYR88 | |
B | TYR88 | |
C | TYR88 | |
D | TYR88 | |
E | TYR88 | |
F | TYR88 |
site_id | SWS_FT_FI5 |
Number of Residues | 24 |
Details | BINDING: BINDING => ECO:0000269|PubMed:14706628, ECO:0000269|PubMed:23438750, ECO:0000305|PubMed:1763067, ECO:0007744|PDB:1RCT, ECO:0007744|PDB:1ULB, ECO:0007744|PDB:4EAR, ECO:0007744|PDB:4EB8, ECO:0007744|PDB:4GKA |
Chain | Residue | Details |
A | ALA116 | |
C | GLU201 | |
C | SER220 | |
C | ASN243 | |
D | ALA116 | |
D | GLU201 | |
D | SER220 | |
D | ASN243 | |
E | ALA116 | |
E | GLU201 | |
E | SER220 | |
A | GLU201 | |
E | ASN243 | |
F | ALA116 | |
F | GLU201 | |
F | SER220 | |
F | ASN243 | |
A | SER220 | |
A | ASN243 | |
B | ALA116 | |
B | GLU201 | |
B | SER220 | |
B | ASN243 | |
C | ALA116 |
site_id | SWS_FT_FI6 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:14706628, ECO:0007744|PDB:1RCT |
Chain | Residue | Details |
A | MET219 | |
E | HIS257 | |
F | MET219 | |
F | HIS257 | |
A | HIS257 | |
B | MET219 | |
B | HIS257 | |
C | MET219 | |
C | HIS257 | |
D | MET219 | |
D | HIS257 | |
E | MET219 |
site_id | SWS_FT_FI7 |
Number of Residues | 6 |
Details | SITE: Important for substrate specificity => ECO:0000269|PubMed:9305964 |
Chain | Residue | Details |
A | ASN243 | |
B | ASN243 | |
C | ASN243 | |
D | ASN243 | |
E | ASN243 | |
F | ASN243 |
site_id | SWS_FT_FI8 |
Number of Residues | 6 |
Details | MOD_RES: N-acetylmethionine => ECO:0000269|Ref.8, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895 |
Chain | Residue | Details |
A | MET1 | |
B | MET1 | |
C | MET1 | |
D | MET1 | |
E | MET1 | |
F | MET1 |
site_id | SWS_FT_FI9 |
Number of Residues | 6 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER251 | |
B | SER251 | |
C | SER251 | |
D | SER251 | |
E | SER251 | |
F | SER251 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 10 |
Details | M-CSA 17 |
Chain | Residue | Details |
A | SER33 | hydrogen bond donor |
A | HIS257 | electrostatic stabiliser, hydrogen bond acceptor |
A | HIS64 | electrostatic stabiliser |
A | HIS86 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
A | TYR88 | electrostatic stabiliser, hydrogen bond donor |
A | GLU89 | activator, electrostatic stabiliser, hydrogen bond acceptor |
A | ALA116 | electrostatic stabiliser, hydrogen bond donor |
A | MET219 | electrostatic stabiliser, hydrogen bond donor |
A | SER220 | electrostatic stabiliser, hydrogen bond donor |
A | ASN243 | electrostatic stabiliser, hydrogen bond donor, polar interaction |
site_id | MCSA2 |
Number of Residues | 10 |
Details | M-CSA 17 |
Chain | Residue | Details |
B | SER33 | hydrogen bond donor |
B | HIS257 | electrostatic stabiliser, hydrogen bond acceptor |
B | HIS64 | electrostatic stabiliser |
B | HIS86 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
B | TYR88 | electrostatic stabiliser, hydrogen bond donor |
B | GLU89 | activator, electrostatic stabiliser, hydrogen bond acceptor |
B | ALA116 | electrostatic stabiliser, hydrogen bond donor |
B | MET219 | electrostatic stabiliser, hydrogen bond donor |
B | SER220 | electrostatic stabiliser, hydrogen bond donor |
B | ASN243 | electrostatic stabiliser, hydrogen bond donor, polar interaction |
site_id | MCSA3 |
Number of Residues | 10 |
Details | M-CSA 17 |
Chain | Residue | Details |
C | SER33 | hydrogen bond donor |
C | HIS257 | electrostatic stabiliser, hydrogen bond acceptor |
C | HIS64 | electrostatic stabiliser |
C | HIS86 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
C | TYR88 | electrostatic stabiliser, hydrogen bond donor |
C | GLU89 | activator, electrostatic stabiliser, hydrogen bond acceptor |
C | ALA116 | electrostatic stabiliser, hydrogen bond donor |
C | MET219 | electrostatic stabiliser, hydrogen bond donor |
C | SER220 | electrostatic stabiliser, hydrogen bond donor |
C | ASN243 | electrostatic stabiliser, hydrogen bond donor, polar interaction |
site_id | MCSA4 |
Number of Residues | 10 |
Details | M-CSA 17 |
Chain | Residue | Details |
D | SER33 | hydrogen bond donor |
D | HIS257 | electrostatic stabiliser, hydrogen bond acceptor |
D | HIS64 | electrostatic stabiliser |
D | HIS86 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
D | TYR88 | electrostatic stabiliser, hydrogen bond donor |
D | GLU89 | activator, electrostatic stabiliser, hydrogen bond acceptor |
D | ALA116 | electrostatic stabiliser, hydrogen bond donor |
D | MET219 | electrostatic stabiliser, hydrogen bond donor |
D | SER220 | electrostatic stabiliser, hydrogen bond donor |
D | ASN243 | electrostatic stabiliser, hydrogen bond donor, polar interaction |
site_id | MCSA5 |
Number of Residues | 10 |
Details | M-CSA 17 |
Chain | Residue | Details |
E | SER33 | hydrogen bond donor |
E | HIS257 | electrostatic stabiliser, hydrogen bond acceptor |
E | HIS64 | electrostatic stabiliser |
E | HIS86 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
E | TYR88 | electrostatic stabiliser, hydrogen bond donor |
E | GLU89 | activator, electrostatic stabiliser, hydrogen bond acceptor |
E | ALA116 | electrostatic stabiliser, hydrogen bond donor |
E | MET219 | electrostatic stabiliser, hydrogen bond donor |
E | SER220 | electrostatic stabiliser, hydrogen bond donor |
E | ASN243 | electrostatic stabiliser, hydrogen bond donor, polar interaction |
site_id | MCSA6 |
Number of Residues | 10 |
Details | M-CSA 17 |
Chain | Residue | Details |
F | SER33 | hydrogen bond donor |
F | HIS257 | electrostatic stabiliser, hydrogen bond acceptor |
F | HIS64 | electrostatic stabiliser |
F | HIS86 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
F | TYR88 | electrostatic stabiliser, hydrogen bond donor |
F | GLU89 | activator, electrostatic stabiliser, hydrogen bond acceptor |
F | ALA116 | electrostatic stabiliser, hydrogen bond donor |
F | MET219 | electrostatic stabiliser, hydrogen bond donor |
F | SER220 | electrostatic stabiliser, hydrogen bond donor |
F | ASN243 | electrostatic stabiliser, hydrogen bond donor, polar interaction |