2MWX
| The RING Domain of human Promyelocytic Leukemia Protein (PML) | Descriptor: | Protein PML, ZINC ION | Authors: | Huang, S.Y, Chang, C.F, Fan, P.J, Guntert, P, Shih, H.M, Huang, T.H. | Deposit date: | 2014-12-02 | Release date: | 2015-02-11 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The RING domain of human promyelocytic leukemia protein (PML). J.Biomol.Nmr, 61, 2015
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2ECW
| Solution structure of the Zinc finger, C3HC4 type (RING finger) domain Tripartite motif protein 30 | Descriptor: | Tripartite motif-containing protein 30, ZINC ION | Authors: | Abe, H, Miyamoto, K, Tochio, N, Yoneyama, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-02-14 | Release date: | 2008-02-26 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the Zinc finger, C3HC4 type (RING finger) domain Tripartite motif protein 30 To be Published
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4R7E
| Structure of Bre1 RING domain | Descriptor: | E3 ubiquitin-protein ligase BRE1, ZINC ION | Authors: | Kumar, P, Wolberger, C. | Deposit date: | 2014-08-27 | Release date: | 2015-05-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.251 Å) | Cite: | Structure of the yeast Bre1 RING domain. Proteins, 83, 2015
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1BOR
| TRANSCRIPTION FACTOR PML, A PROTO-ONCOPROTEIN, NMR, 1 REPRESENTATIVE STRUCTURE AT PH 7.5, 30 C, IN THE PRESENCE OF ZINC | Descriptor: | TRANSCRIPTION FACTOR PML, ZINC ION | Authors: | Borden, K.L.B, Freemont, P.S. | Deposit date: | 1995-09-27 | Release date: | 1997-04-01 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | The solution structure of the RING finger domain from the acute promyelocytic leukaemia proto-oncoprotein PML. EMBO J., 14, 1995
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1CHC
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2K4D
| E2-c-Cbl recognition is necessary but not sufficient for ubiquitination activity | Descriptor: | E3 ubiquitin-protein ligase CBL, ZINC ION | Authors: | Huang, A, De Jong, R.N, Wienk, H, Winkler, S.G, Timmers, H.T.M, Boelens, R. | Deposit date: | 2008-06-06 | Release date: | 2009-01-20 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | E2-c-Cbl recognition is necessary but not sufficient for ubiquitination activity J.Mol.Biol., 385, 2009
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2LDR
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5H7R
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5TRB
| Crystal structure of the RNF20 RING domain | Descriptor: | E3 ubiquitin-protein ligase BRE1A, ZINC ION | Authors: | Foglizzo, M, Middleton, A.J, Day, C.L. | Deposit date: | 2016-10-25 | Release date: | 2016-11-02 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure and Function of the RING Domains of RNF20 and RNF40, Dimeric E3 Ligases that Monoubiquitylate Histone H2B. J.Mol.Biol., 428, 2016
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5YUF
| Crystal Structure of PML RING tetramer | Descriptor: | Protein PML, ZINC ION | Authors: | Wang, P, Benhend, S, Wu, H, Breitenbach, V, Zhen, T, Jollivet, F, Peres, L, Li, Y, Chen, S, Chen, Z, de THE, H, Meng, G. | Deposit date: | 2017-11-22 | Release date: | 2018-04-11 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | RING tetramerization is required for nuclear body biogenesis and PML sumoylation. Nat Commun, 9, 2018
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5HKX
| Crystal Structure of c-Cbl TKBD-RING domains (Y371E mutant) Refined to 1.85 A Resolution | Descriptor: | 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase CBL, SODIUM ION, ... | Authors: | Lovell, S, Battaile, K.P, Mehzabeen, N, Zhang, N, Cooper, A, Gao, P, Perez, R.P. | Deposit date: | 2016-01-14 | Release date: | 2017-01-18 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Crystal Structure of c-Cbl TKBD-RING domains (Y371E mutant) Refined to 1.85 A Resolution To be published
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4KC9
| Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism | Descriptor: | E3 ubiquitin-protein ligase ARIH1, ZINC ION | Authors: | Duda, D.M, Olszewski, J.L, Schulman, B.A. | Deposit date: | 2013-04-24 | Release date: | 2013-05-29 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (3.603 Å) | Cite: | Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism. Structure, 21, 2013
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5J3X
| Structure of c-CBL Y371F | Descriptor: | CALCIUM ION, E3 ubiquitin-protein ligase CBL, ZINC ION | Authors: | Huang, D.T, Buetow, L, Dou, H. | Deposit date: | 2016-03-31 | Release date: | 2016-09-21 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.822 Å) | Cite: | Casitas B-lineage lymphoma linker helix mutations found in myeloproliferative neoplasms affect conformation. Bmc Biol., 14, 2016
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6S53
| Crystal structure of TRIM21 RING domain in complex with an isopeptide-linked Ube2N~ubiquitin conjugate | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, E3 ubiquitin-protein ligase TRIM21, Polyubiquitin-C, ... | Authors: | Kiss, L, Boland, A, Neuhaus, D, James, L.C. | Deposit date: | 2019-06-30 | Release date: | 2019-09-11 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | A tri-ionic anchor mechanism drives Ube2N-specific recruitment and K63-chain ubiquitination in TRIM ligases. Nat Commun, 10, 2019
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1FBV
| STRUCTURE OF A CBL-UBCH7 COMPLEX: RING DOMAIN FUNCTION IN UBIQUITIN-PROTEIN LIGASES | Descriptor: | SIGNAL TRANSDUCTION PROTEIN CBL, SULFATE ION, UBIQUITIN-CONJUGATING ENZYME E12-18 KDA UBCH7, ... | Authors: | Zheng, N, Wang, P, Jeffrey, P.D, Pavletich, N.P. | Deposit date: | 2000-07-17 | Release date: | 2000-08-30 | Last modified: | 2017-10-04 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases. Cell(Cambridge,Mass.), 102, 2000
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1JM7
| Solution structure of the BRCA1/BARD1 RING-domain heterodimer | Descriptor: | BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1, BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN, ZINC ION | Authors: | Brzovic, P.S, Rajagopal, P, Hoyt, D.W, King, M.-C, Klevit, R.E. | Deposit date: | 2001-07-17 | Release date: | 2001-10-03 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure of a BRCA1-BARD1 heterodimeric RING-RING complex. Nat.Struct.Biol., 8, 2001
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7JZV
| Cryo-EM structure of the BRCA1-UbcH5c/BARD1 E3-E2 module bound to a nucleosome | Descriptor: | BRCA1,Ubiquitin-conjugating enzyme E2 D3, BRCA1-associated RING domain protein 1, Histone H2A type 2-A, ... | Authors: | Witus, S.R, Burrell, A.L, Hansen, J.M, Farrell, D.P, Dimaio, F, Kollman, J.M, Klevit, R.E. | Deposit date: | 2020-09-02 | Release date: | 2021-02-17 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | BRCA1/BARD1 site-specific ubiquitylation of nucleosomal H2A is directed by BARD1. Nat.Struct.Mol.Biol., 28, 2021
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7LYB
| Cryo-EM structure of the human nucleosome core particle in complex with BRCA1-BARD1-UbcH5c | Descriptor: | BRCA1-associated RING domain protein 1, DNA (146-MER), DNA (147-MER), ... | Authors: | Hu, Q, Botuyan, M.V, Zhao, D, Cui, D, Mer, E, Mer, G. | Deposit date: | 2021-03-06 | Release date: | 2021-07-28 | Last modified: | 2021-09-01 | Method: | ELECTRON MICROSCOPY (3.28 Å) | Cite: | Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation. Nature, 596, 2021
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7BBD
| Crystal structure of monoubiquitinated TRIM21 RING (Ub-RING) In complex with ubiquitin charged Ube2N (Ube2N~Ub) and Ube2V2 | Descriptor: | Polyubiquitin-B,E3 ubiquitin-protein ligase TRIM21, Polyubiquitin-C, Ubiquitin-conjugating enzyme E2 N, ... | Authors: | Kiss, L, Neuhaus, D, James, L.C. | Deposit date: | 2020-12-17 | Release date: | 2021-01-27 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | RING domains act as both substrate and enzyme in a catalytic arrangement to drive self-anchored ubiquitination. Nat Commun, 12, 2021
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1RMD
| RAG1 DIMERIZATION DOMAIN | Descriptor: | RAG1, ZINC ION | Authors: | Bellon, S.F, Rodgers, K.K, Schatz, D.G, Coleman, J.E, Steitz, T.A. | Deposit date: | 1997-01-10 | Release date: | 1997-07-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of the RAG1 dimerization domain reveals multiple zinc-binding motifs including a novel zinc binuclear cluster. Nat.Struct.Biol., 4, 1997
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4KBL
| Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism | Descriptor: | E3 ubiquitin-protein ligase ARIH1, ZINC ION | Authors: | Duda, D.M, Olszewski, J.L, Schulman, B.A. | Deposit date: | 2013-04-23 | Release date: | 2013-05-29 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism. Structure, 21, 2013
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8A58
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6L8O
| Crystal structure of the K. lactis Rad5 (Hg-derivative) | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DNA repair protein RAD5, MERCURY (II) ION | Authors: | Shen, M, Xiang, S. | Deposit date: | 2019-11-06 | Release date: | 2020-11-11 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structural basis for the multi-activity factor Rad5 in replication stress tolerance. Nat Commun, 12, 2021
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6L8N
| Crystal structure of the K. lactis Rad5 | Descriptor: | DNA repair protein RAD5, ZINC ION | Authors: | Shen, M, Xiang, S. | Deposit date: | 2019-11-06 | Release date: | 2020-11-11 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Structural basis for the multi-activity factor Rad5 in replication stress tolerance. Nat Commun, 12, 2021
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5O76
| Structure of phosphoY371 c-CBL in complex with ZAP70-peptide and UbV.pCBL ubiquitin variant | Descriptor: | CALCIUM ION, E3 ubiquitin-protein ligase CBL, Tyrosine protein kinase ZAP70 peptide, ... | Authors: | Gabrielsen, M, Buetow, L, Huang, D.T. | Deposit date: | 2017-06-08 | Release date: | 2017-11-01 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.473 Å) | Cite: | A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants. Mol. Cell, 68, 2017
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