1JM7
Solution structure of the BRCA1/BARD1 RING-domain heterodimer
Summary for 1JM7
| Entry DOI | 10.2210/pdb1jm7/pdb |
| Descriptor | BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN, BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1, ZINC ION (3 entities in total) |
| Functional Keywords | brca1, bard1, ring finger, zinc-binding protein, heterodimer, ubiquitin ligase, antitumor |
| Biological source | Homo sapiens (human) More |
| Cellular location | Nucleus. Isoform 3: Cytoplasm. Isoform 5: Cytoplasm: P38398 Nucleus: Q99728 |
| Total number of polymer chains | 2 |
| Total formula weight | 26250.05 |
| Authors | Brzovic, P.S.,Rajagopal, P.,Hoyt, D.W.,King, M.-C.,Klevit, R.E. (deposition date: 2001-07-17, release date: 2001-10-03, Last modification date: 2022-02-23) |
| Primary citation | Brzovic, P.S.,Rajagopal, P.,Hoyt, D.W.,King, M.C.,Klevit, R.E. Structure of a BRCA1-BARD1 heterodimeric RING-RING complex. Nat.Struct.Biol., 8:833-837, 2001 Cited by PubMed: 11573085DOI: 10.1038/nsb1001-833 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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