7JZV
Cryo-EM structure of the BRCA1-UbcH5c/BARD1 E3-E2 module bound to a nucleosome
Summary for 7JZV
Entry DOI | 10.2210/pdb7jzv/pdb |
EMDB information | 22581 |
Descriptor | BRCA1,Ubiquitin-conjugating enzyme E2 D3, BRCA1-associated RING domain protein 1, Histone H2A type 2-A, ... (9 entities in total) |
Functional Keywords | complex, ubiquitin, nucleosome, ring, ligase, ligase-dna complex, ligase/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 12 |
Total formula weight | 245918.93 |
Authors | Witus, S.R.,Burrell, A.L.,Hansen, J.M.,Farrell, D.P.,Dimaio, F.,Kollman, J.M.,Klevit, R.E. (deposition date: 2020-09-02, release date: 2021-02-17, Last modification date: 2024-03-06) |
Primary citation | Witus, S.R.,Burrell, A.L.,Farrell, D.P.,Kang, J.,Wang, M.,Hansen, J.M.,Pravat, A.,Tuttle, L.M.,Stewart, M.D.,Brzovic, P.S.,Chatterjee, C.,Zhao, W.,DiMaio, F.,Kollman, J.M.,Klevit, R.E. BRCA1/BARD1 site-specific ubiquitylation of nucleosomal H2A is directed by BARD1. Nat.Struct.Mol.Biol., 28:268-277, 2021 Cited by PubMed: 33589814DOI: 10.1038/s41594-020-00556-4 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.9 Å) |
Structure validation
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