1MV3
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1MUZ
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1CK1
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5PZM
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3FRY
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![BU of 3fry by Molmil](/molmil-images/mine/3fry) | Crystal structure of the CopA C-terminal metal binding domain | Descriptor: | CITRIC ACID, Probable copper-exporting P-type ATPase A | Authors: | Agarwal, S, Sazinsky, M, Arguello, J, Rosenzweig, A.C. | Deposit date: | 2009-01-08 | Release date: | 2010-01-12 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure and interactions of the C-terminal metal binding domain of Archaeoglobus fulgidus CopA. Proteins, 78, 2010
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2YKI
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![BU of 2yki by Molmil](/molmil-images/mine/2yki) | Tricyclic series of Hsp90 inhibitors | Descriptor: | 1-H-PYRROLO[2,3-B]PYRIDINE-4-CARBOXYLIC ACID [4-(3H-IMIDAZO[4,5-C]PYRIDIN-2-YL)-9H-FLUOREN-9-YL]-AMIDE, HEAT SHOCK PROTEIN HSP 90-ALPHA | Authors: | Dupuy, A, Vallee, F. | Deposit date: | 2011-05-27 | Release date: | 2011-10-19 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-C]Pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone. J.Med.Chem., 54, 2011
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1LBK
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![BU of 1lbk by Molmil](/molmil-images/mine/1lbk) | Crystal structure of a recombinant glutathione transferase, created by replacing the last seven residues of each subunit of the human class pi isoenzyme with the additional C-terminal helix of human class alpha isoenzyme | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE, Glutathione S-transferase class pi chimaera (CODA), ... | Authors: | Kong, G.K.W, Micaloni, C, Mazzetti, A.P, Nuccetelli, M, Antonini, G, Stella, L, McKinstry, W.J, Polekhina, G, Rossjohn, J, Federici, G, Ricci, G, Parker, M.W, Lo Bello, M. | Deposit date: | 2002-04-04 | Release date: | 2002-04-17 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Engineering a new C-terminal tail in the H-site of human glutathione transferase P1-1: structural and functional consequences. J.Mol.Biol., 325, 2003
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6BNA
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![BU of 6bna by Molmil](/molmil-images/mine/6bna) | BINDING OF AN ANTITUMOR DRUG TO DNA. NETROPSIN AND C-G-C-G-A-A-T-T-BRC-G-C-G | Descriptor: | DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*(CBR)P*GP*CP*G)-3'), NETROPSIN | Authors: | Kopka, M.L, Yoon, C, Goodsell, D, Pjura, P, Dickerson, R.E. | Deposit date: | 1984-08-30 | Release date: | 1984-10-29 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Binding of an antitumor drug to DNA, Netropsin and C-G-C-G-A-A-T-T-BrC-G-C-G. J.Mol.Biol., 183, 1985
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5TRY
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![BU of 5try by Molmil](/molmil-images/mine/5try) | Structure of Mycobacterium tuberculosis proteasome in complex with N,C-capped dipeptide PKS2206 | Descriptor: | (2~{S})-~{N}-[(2~{S})-3-methoxy-1-(naphthalen-1-ylmethylamino)-1-oxidanylidene-propan-2-yl]-4-oxidanylidene-2-(3-phenylpropanoylamino)-4-piperidin-1-yl-butanamide, Proteasome subunit alpha, Proteasome subunit beta | Authors: | Hsu, H.-C, Fan, H, Singh, P.K, Wang, R, Sukenick, G, Nathan, C, Lin, G, Li, H. | Deposit date: | 2016-10-27 | Release date: | 2017-01-11 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.000008 Å) | Cite: | Structural Basis for the Species-Selective Binding of N,C-Capped Dipeptides to the Mycobacterium tuberculosis Proteasome. Biochemistry, 56, 2017
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5TS0
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![BU of 5ts0 by Molmil](/molmil-images/mine/5ts0) | Structure of Mycobacterium tuberculosis proteasome in complex with N,C-capped dipeptide PKS2208 | Descriptor: | (2S)-N-{(2S)-3-methoxy-1-[(naphthalen-1-ylmethyl)amino]-1-oxopropan-2-yl}-4-oxo-2-[(3-phenylpropanoyl)amino]-4-(1H-pyrrol-1-yl)butanamide (non-preferred name), Proteasome subunit alpha, Proteasome subunit beta | Authors: | Hsu, H.-C, Fan, H, Singh, P.K, Wang, R, Sukenick, G, Nathan, C, Lin, G, Li, H. | Deposit date: | 2016-10-27 | Release date: | 2017-01-11 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.84679747 Å) | Cite: | Structural Basis for the Species-Selective Binding of N,C-Capped Dipeptides to the Mycobacterium tuberculosis Proteasome. Biochemistry, 56, 2017
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4BH6
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![BU of 4bh6 by Molmil](/molmil-images/mine/4bh6) | Insights into degron recognition by APC coactivators from the structure of an Acm1-Cdh1 complex | Descriptor: | APC/C ACTIVATOR PROTEIN CDH1, APC/C-CDH1 MODULATOR 1 | Authors: | He, J, Chao, W.C.H, Zhang, Z, Yang, J, Cronin, N, Barford, D. | Deposit date: | 2013-03-29 | Release date: | 2013-06-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Insights Into Degron Recognition by Apc/C Coactivators from the Structure of an Acm1-Cdh1 Complex. Mol.Cell, 50, 2013
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100D
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2YCC
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7CLZ
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161D
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4AC8
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![BU of 4ac8 by Molmil](/molmil-images/mine/4ac8) | R2-like ligand binding Mn-Fe oxidase from M. tuberculosis with an organized C-terminal helix | Descriptor: | CALCIUM ION, FE (III) ION, GLYCEROL, ... | Authors: | Andersson, C.S, Berthold, C.L, Hogbom, M. | Deposit date: | 2011-12-14 | Release date: | 2012-09-26 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | A Dynamic C-Terminal Segment in the Mycobacterium Tuberculosis Mn/Fe R2Lox Protein Can Adopt a Helical Structure with Possible Functional Consequences. Chem.Biodivers., 9, 2012
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7VBT
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![BU of 7vbt by Molmil](/molmil-images/mine/7vbt) | Crystal structure of RIOK2 in complex with CQ211 | Descriptor: | 8-(6-methoxypyridin-3-yl)-1-[4-piperazin-1-yl-3-(trifluoromethyl)phenyl]-5H-[1,2,3]triazolo[4,5-c]quinolin-4-one, Serine/threonine-protein kinase RIO2 | Authors: | Zhu, C, Zhang, Z.M. | Deposit date: | 2021-09-01 | Release date: | 2022-07-06 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.54001474 Å) | Cite: | Discovery of 8-(6-Methoxypyridin-3-yl)-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)-1,5-dihydro- 4H -[1,2,3]triazolo[4,5- c ]quinolin-4-one (CQ211) as a Highly Potent and Selective RIOK2 Inhibitor. J.Med.Chem., 65, 2022
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1KNK
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![BU of 1knk by Molmil](/molmil-images/mine/1knk) | Crystal Structure of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate Synthase (ispF) from E. coli involved in Mevalonate-Independent Isoprenoid Biosynthesis | Descriptor: | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MANGANESE (II) ION | Authors: | Richard, S.B, Ferrer, J.L, Bowman, M.E, Lillo, A.M, Tetzlaff, C.N, Cane, D.E, Noel, J.P. | Deposit date: | 2001-12-18 | Release date: | 2002-06-18 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway. J.Biol.Chem., 277, 2002
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7VU7
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2ZJO
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![BU of 2zjo by Molmil](/molmil-images/mine/2zjo) | Crystal structure of hepatitis C virus NS3 helicase with a novel inhibitor | Descriptor: | Genome polyprotein, N-[4-(BIS{4-[(3-SULFOPHENYL)AMINO]PHENYL}METHYLENE)CYCLOHEXA-2,5-DIEN-1-YLIDENE]-4-SULFOBENZENAMINIUM | Authors: | Liaw, S.H, Chen, S.J, Hu, C.Y, Chi, W.K, Chu, I.D, Hwang, L.H, Chern, J.W, Chen, D.S. | Deposit date: | 2008-03-07 | Release date: | 2009-03-10 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure-Based Discovery of Triphenylmethane Derivatives as Novel Inhibitors of Hepatitis C Virus Helicase To be Published
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1W87
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8U0G
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2XI3
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![BU of 2xi3 by Molmil](/molmil-images/mine/2xi3) | HCV-H77 NS5B Polymerase Complexed With GTP | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RNA-directed RNA polymerase | Authors: | Harrus, D, Ahmed-El-Sayed, N, Simister, P.C, Miller, S, Triconnet, M, Hagedorn, C.H, Mahias, K, Rey, F.A, Astier-Gin, T, Bressanelli, S. | Deposit date: | 2010-06-25 | Release date: | 2010-08-04 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Further Insights Into the Roles of GTP and the C- Terminus of the Hepatitis C Virus Polymerase in the Initiation of RNA Synthesis J.Biol.Chem., 285, 2010
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1W34
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![BU of 1w34 by Molmil](/molmil-images/mine/1w34) | FERREDOXIN-NADP REDUCTASE (MUTATION: Y 303 S) | Descriptor: | FERREDOXIN-NADP REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION | Authors: | Hermoso, J.A, Perez-Dorado, I, Medina, M, Julvez, M.M, Sanz-Aparicio, J, Gomez-Moreno, C. | Deposit date: | 2004-07-13 | Release date: | 2005-10-19 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | C-Terminal Tyrosine of Ferredoxin-Nadp(+) Reductase in Hydride Transfer Processes with Nad(P)(+)/H. Biochemistry, 44, 2005
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6LUS
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![BU of 6lus by Molmil](/molmil-images/mine/6lus) | Crystal structure of the Mengla Virus VP30 C-terminal domain | Descriptor: | Minor nucleoprotein VP30 | Authors: | Dong, S.S, Wen, K.N, Chu, H.G, Wang, C.H, Qin, X.C. | Deposit date: | 2020-01-30 | Release date: | 2020-12-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Crystal structure of the Mengla virus VP30 C-terminal domain. Biochem.Biophys.Res.Commun., 525, 2020
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