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3KNX

HCV NS3 protease domain with P1-P3 macrocyclic ketoamide inhibitor

Summary for 3KNX
Entry DOI10.2210/pdb3knx/pdb
Related3EYD
DescriptorHCV NS3 Protease, HCV NS4a peptide, ZINC ION, ... (6 entities in total)
Functional Keywordshepatitis c virus, ns3 protease domain, serine protease, macrocyclic ketoamide inhibitor, atp-binding, envelope protein, helicase, hydrolase, membrane, nucleotide-binding, rna replication, transmembrane, viral protein
Biological sourceHepatitis C virus subtype 1a
More
Total number of polymer chains4
Total formula weight48192.44
Authors
Primary citationVenkatraman, S.,Velazquez, F.,Wu, W.,Blackman, M.,Chen, K.X.,Bogen, S.,Nair, L.,Tong, X.,Chase, R.,Hart, A.,Agrawal, S.,Pichardo, J.,Prongay, A.,Cheng, K.C.,Girijavallabhan, V.,Piwinski, J.,Shih, N.Y.,Njoroge, F.G.
Discovery and structure-activity relationship of P1-P3 ketoamide derived macrocyclic inhibitors of hepatitis C virus NS3 protease.
J.Med.Chem., 52:336-346, 2009
Cited by
PubMed: 19102654
DOI: 10.1021/jm800940u
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.65 Å)
Structure validation

217705

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