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1A7H

GAMMA S CRYSTALLIN C-TERMINAL DOMAIN

Summary for 1A7H
Entry DOI10.2210/pdb1a7h/pdb
DescriptorGAMMAS CRYSTALLIN (2 entities in total)
Functional Keywordseye-lens protein, gamma crystallin s, eye lens protein, multigene family
Biological sourceBos taurus (cattle)
Total number of polymer chains2
Total formula weight20639.54
Authors
Basak, A.K.,Slingsby, C. (deposition date: 1998-03-13, release date: 1998-05-27, Last modification date: 2024-04-03)
Primary citationBasak, A.K.,Kroone, R.C.,Lubsen, N.H.,Naylor, C.E.,Jaenicke, R.,Slingsby, C.
The C-terminal domains of gammaS-crystallin pair about a distorted twofold axis.
Protein Eng., 11:337-344, 1998
Cited by
PubMed Abstract: The 2-domain gammaS-crystallin, a highly conserved early evolutionary off-shoot of the gamma-crystallin family, is located in the water-rich region of eye lenses. The expressed C-terminal domain, gammaS-C, has been crystallized and the 2.56 A X-ray structure determined. There are two domains in the asymmetric unit which pair about a distorted twofold axis. One of the domains has an altered conformation in a highly conserved region of the protein, the tyrosine corner. The distorted gammaS-C dimer of domains is compared with the highly symmetrical, equivalent recombinant dimer of C-terminal domains from gammaB-crystallin. Sequence changes close to the interface, that distinguish gammaS from the other gamma-crystallins, are examined in order to evaluate their role in symmetrical domain pairing.
PubMed: 9681865
DOI: 10.1093/protein/11.5.337
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.56 Å)
Structure validation

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