1A7H
GAMMA S CRYSTALLIN C-TERMINAL DOMAIN
Summary for 1A7H
| Entry DOI | 10.2210/pdb1a7h/pdb |
| Descriptor | GAMMAS CRYSTALLIN (2 entities in total) |
| Functional Keywords | eye-lens protein, gamma crystallin s, eye lens protein, multigene family |
| Biological source | Bos taurus (cattle) |
| Total number of polymer chains | 2 |
| Total formula weight | 20639.54 |
| Authors | Basak, A.K.,Slingsby, C. (deposition date: 1998-03-13, release date: 1998-05-27, Last modification date: 2024-04-03) |
| Primary citation | Basak, A.K.,Kroone, R.C.,Lubsen, N.H.,Naylor, C.E.,Jaenicke, R.,Slingsby, C. The C-terminal domains of gammaS-crystallin pair about a distorted twofold axis. Protein Eng., 11:337-344, 1998 Cited by PubMed Abstract: The 2-domain gammaS-crystallin, a highly conserved early evolutionary off-shoot of the gamma-crystallin family, is located in the water-rich region of eye lenses. The expressed C-terminal domain, gammaS-C, has been crystallized and the 2.56 A X-ray structure determined. There are two domains in the asymmetric unit which pair about a distorted twofold axis. One of the domains has an altered conformation in a highly conserved region of the protein, the tyrosine corner. The distorted gammaS-C dimer of domains is compared with the highly symmetrical, equivalent recombinant dimer of C-terminal domains from gammaB-crystallin. Sequence changes close to the interface, that distinguish gammaS from the other gamma-crystallins, are examined in order to evaluate their role in symmetrical domain pairing. PubMed: 9681865DOI: 10.1093/protein/11.5.337 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.56 Å) |
Structure validation
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