3EL7

Crystal structure of c-Src in complex with pyrazolopyrimidine 3

Summary for 3EL7

Entry DOI	10.2210/pdb3el7/pdb
Related	3EL8
Descriptor	Proto-oncogene tyrosine-protein kinase Src, 1-{3-[(4-amino-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)methyl]phenyl}-3-[3-(trifluoromethyl)phenyl]urea (3 entities in total)
Functional Keywords	kinase, c-src, pyrazolopyrimidine, atp-binding, lipoprotein, myristate, nucleotide-binding, phosphoprotein, proto-oncogene, sh2 domain, sh3 domain, transferase, tyrosine-protein kinase
Biological source	Gallus gallus (chicken)
Cellular location	Cell membrane (By similarity): P00523
Total number of polymer chains	1
Total formula weight	33222.15
Authors	Dar, A.C.,Lopez, M.S.,Shokat, K.M. (deposition date: 2008-09-20, release date: 2008-10-28, Last modification date: 2023-08-30)
Primary citation	Dar, A.C.,Lopez, M.S.,Shokat, K.M. Small molecule recognition of c-Src via the Imatinib-binding conformation. Chem.Biol., 15:1015-1022, 2008 Cited by PubMed: 18940662 DOI: 10.1016/j.chembiol.2008.09.007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation