3EL7
Crystal structure of c-Src in complex with pyrazolopyrimidine 3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Proto-oncogene tyrosine-protein kinase Src | polymer | 286 | 32726.6 | 1 | UniProt (P00523) Pfam (PF07714) In PDB | Gallus gallus (chicken) | p60-Src, c-Src, pp60c-src |
| 2 | A | 1-{3-[(4-amino-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)methyl]phenyl}-3-[3-(trifluoromethyl)phenyl]urea | non-polymer | 495.5 | 1 | Chemie (PD3) | |||
| 3 | water | water | 18.0 | 59 | Chemie (HOH) |
Sequence modifications
A: 251 - 533 (UniProt: P00523)
| PDB | External Database | Details |
|---|---|---|
| Gly 248 | - | expression tag |
| His 249 | - | expression tag |
| Met 250 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32726.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 495.5 | |
| All* | Total formula weight | 33222.1 |
