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6B1S
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BU of 6b1s by Molmil
Hydrogen Bonding Complementary, not size complementarity is key in the formation of the double helix
Descriptor: DNA (5'-D(*CP*TP*TP*AP*TP*AP*(CGY)P*(CGY)P*TP*TP*TP*AP*TP*AP*AP*G)-3'), Reverse transcriptase
Authors:Singh, I, Georgiadis, M.M.
Deposit date:2017-09-18
Release date:2018-09-19
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:"Skinny" and "Fat" DNA: Two New Double Helices.
J. Am. Chem. Soc., 140, 2018
6B1R
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BU of 6b1r by Molmil
Hydrogen Bonding Complementary, not size complementarity is key in the formation of the double helix
Descriptor: DNA (5'-D(*CP*TP*TP*AP*TP*(1WA)P*(1WA)P*(1WA))-3'), DNA (5'-D(P*(IGU)P*(IGU)P*(IGU)P*AP*TP*AP*AP*G)-3'), Reverse transcriptase
Authors:Singh, I, Georgiadis, M.M.
Deposit date:2017-09-18
Release date:2018-09-19
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:"Skinny" and "Fat" DNA: Two New Double Helices.
J. Am. Chem. Soc., 140, 2018
6BHJ
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BU of 6bhj by Molmil
Structure of HIV-1 Reverse Transcriptase Bound to a 38-mer Hairpin Template-Primer RNA-DNA Aptamer
Descriptor: 38-MER RNA-DNA Aptamer, GLYCEROL, HIV-1 REVERSE TRANSCRIPTASE P51 subunit, ...
Authors:Ruiz, F.X, Miller, M.T, Tuske, S, Das, K, Arnold, E.
Deposit date:2017-10-30
Release date:2018-10-31
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Integrative Structural Biology Studies of HIV-1 Reverse Transcriptase Binding to a High-Affinity DNA Aptamer
Curr Res Struct Biol, 2020
6IK9
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BU of 6ik9 by Molmil
HIV-1 reverse transcriptase with Q151M/G112S/D113A/Y115F/F116Y/F160L/I159L:DNA:dGTP ternary complex
Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA/RNA (38-MER), GLYCEROL, ...
Authors:Yasutake, Y, Hattori, S.I, Tamura, N, Maeda, K.
Deposit date:2018-10-15
Release date:2019-01-30
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.435 Å)
Cite:Active-site deformation in the structure of HIV-1 RT with HBV-associated septuple amino acid substitutions rationalizes the differential susceptibility of HIV-1 and HBV against 4'-modified nucleoside RT inhibitors.
Biochem. Biophys. Res. Commun., 509, 2019
6IKA
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BU of 6ika by Molmil
HIV-1 reverse transcriptase with Q151M/G112S/D113A/Y115F/F116Y/F160L/I159L:DNA:entecavir-triphosphate ternary complex
Descriptor: DNA/RNA (38-MER), GLYCEROL, HIV-1 RT p51 subunit, ...
Authors:Yasutake, Y, Hattori, S.I, Tamura, N, Maeda, K.
Deposit date:2018-10-15
Release date:2019-01-30
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.598 Å)
Cite:Active-site deformation in the structure of HIV-1 RT with HBV-associated septuple amino acid substitutions rationalizes the differential susceptibility of HIV-1 and HBV against 4'-modified nucleoside RT inhibitors.
Biochem. Biophys. Res. Commun., 509, 2019
6MIH
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BU of 6mih by Molmil
Crystal structure of host-guest complex with PC hachimoji DNA
Descriptor: DNA (5'-D(*CP*TP*TP*AP*(1WA)P*CP*(DB)P*T)-3'), DNA (5'-D(P*AP*(DS)P*GP*(1W5)P*TP*AP*AP*G)-3'), N-terminal fragment of MMLV reverse transcriptase
Authors:Georgiadis, M.M.
Deposit date:2018-09-19
Release date:2019-02-27
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Hachimoji DNA and RNA: A genetic system with eight building blocks.
Science, 363, 2019
6MIG
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BU of 6mig by Molmil
Crystal structure of host-guest complex with PB hachimoji DNA
Descriptor: DNA (5'-D(*CP*TP*TP*AP*TP*(1WA)P*(1WA)P*(DS))-3'), DNA (5'-D(P*(DB)P*(1W5)P*(1W5)P*AP*TP*AP*AP*G)-3'), Gag-Pol polyprotein
Authors:Georgiadis, M.M.
Deposit date:2018-09-19
Release date:2019-02-27
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Hachimoji DNA and RNA: A genetic system with eight building blocks.
Science, 363, 2019
6MIK
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BU of 6mik by Molmil
Crystal structure of host-guest complex with PP hachimoji DNA
Descriptor: DNA (5'-D(*CP*TP*TP*AP*TP*(1WA)P*(1WA)P*(DS))-3'), DNA (5'-D(P*(DB)P*(1W5)P*(1W5)P*AP*TP*AP*AP*G)-3'), N-terminal fragment of MMLV reverse transcriptase
Authors:Georgiadis, M.M.
Deposit date:2018-09-19
Release date:2019-02-27
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Hachimoji DNA and RNA: A genetic system with eight building blocks.
Science, 363, 2019
6E53
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BU of 6e53 by Molmil
Structure of TERT in complex with a novel telomerase inhibitor
Descriptor: MAGNESIUM ION, RNA/DNA hairpin, Telomerase reverse transcriptase, ...
Authors:Hernandez-Sanchez, W, Huang, W, Plucinsky, B, Garcia-Vazquez, N, Berdis, A.J, Skordalakes, E, Taylor, D.J.
Deposit date:2018-07-19
Release date:2019-03-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A non-natural nucleotide uses a specific pocket to selectively inhibit telomerase activity.
Plos Biol., 17, 2019
6HAK
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BU of 6hak by Molmil
Crystal structure of HIV-1 reverse transcriptase (RT) in complex with a double stranded RNA represents the RT transcription initiation complex prior to nucleotide incorporation
Descriptor: Gag-Pol polyprotein, MAGNESIUM ION, RNA (5'-R(P*AP*GP*UP*GP*GP*CP*GP*GP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*C)-3'), ...
Authors:Das, K, Martinez, S.E, Arnold, E.
Deposit date:2018-08-07
Release date:2019-04-03
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.95 Å)
Cite:Structure of HIV-1 RT/dsRNA initiation complex prior to nucleotide incorporation.
Proc.Natl.Acad.Sci.USA, 116, 2019
6OE3
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BU of 6oe3 by Molmil
Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-7-fluoro-2-naphthonitrile (JLJ635), a Non-nucleoside Inhibitor
Descriptor: 5-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}-7-fluoronaphthalene-2-carbonitrile, HIV-1 REVERSE TRANSCRIPTASE, P51 SUBUNIT, ...
Authors:Bertoletti, N, Kudalkar, S.N, Anderson, K.S, Cisneros Trigo, J.A, Jorgensen, W.L.
Deposit date:2019-03-27
Release date:2019-05-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural and pharmacological evaluation of a novel non-nucleoside reverse transcriptase inhibitor as a promising long acting nanoformulation for treating HIV.
Antiviral Res., 167, 2019
6P2G
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BU of 6p2g by Molmil
Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and D-ddCTP
Descriptor: 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, DNA Primer 20-mer, DNA template 27-mer, ...
Authors:Bertoletti, N, Anderson, K.S.
Deposit date:2019-05-21
Release date:2019-07-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV-1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine.
Protein Sci., 28, 2019
6P1I
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BU of 6p1i by Molmil
Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and dCTP
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA Primer 20-mer, DNA template 27-mer, ...
Authors:Bertoletti, N, Anderson, K.S.
Deposit date:2019-05-19
Release date:2019-07-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV-1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine.
Protein Sci., 28, 2019
6P1X
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BU of 6p1x by Molmil
Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and L-ddCTP
Descriptor: DNA Primer 20-mer, DNA template 27-mer, MAGNESIUM ION, ...
Authors:Bertoletti, N, Anderson, K.S.
Deposit date:2019-05-20
Release date:2019-07-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.553 Å)
Cite:Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV-1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine.
Protein Sci., 28, 2019
6OUN
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BU of 6oun by Molmil
Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and (-)3TC-TP
Descriptor: DNA primer 20-mer, DNA template 27-mer, Lamivudine Triphosphate, ...
Authors:Bertoletti, N, Anderson, K.S.
Deposit date:2019-05-04
Release date:2019-07-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.656 Å)
Cite:Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV-1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine.
Protein Sci., 28, 2019
6OR7
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BU of 6or7 by Molmil
Structure of HIV-1 Reverse Transcriptase (RT) in complex with DNA AND (-)FTC-TP
Descriptor: DNA Primer 20-mer, DNA template 27-mer, MAGNESIUM ION, ...
Authors:Bertoletti, N, Chan, A.H, Anderson, K.S.
Deposit date:2019-04-29
Release date:2019-07-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV-1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine.
Protein Sci., 28, 2019
6OTZ
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BU of 6otz by Molmil
Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and (+)FTC-TP
Descriptor: DNA Primer 20-mer, DNA template 27-mer, GLYCEROL, ...
Authors:Bertoletti, N, Anderson, K.S.
Deposit date:2019-05-03
Release date:2019-07-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.857 Å)
Cite:Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV-1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine.
Protein Sci., 28, 2019
6DTX
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BU of 6dtx by Molmil
Wildtype HIV-1 Reverse Transcriptase in complex with JLJ 578
Descriptor: 8-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]-4-fluorophenoxy}-6-fluoroindolizine-2-carbonitrile, GLYCEROL, Reverse transcriptase/ribonuclease H, ...
Authors:Sasaki, T, Gannam, Z.T.K, Anderson, K.S, Jorgensen, W.L, Lee, W.
Deposit date:2018-06-18
Release date:2019-07-31
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.327 Å)
Cite:Molecular and cellular studies evaluating a potent 2-cyanoindolizine catechol diether NNRTI targeting wildtype and Y181C mutant HIV-1 reverse transcriptase.
Bioorg.Med.Chem.Lett., 29, 2019
6DTW
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BU of 6dtw by Molmil
HIV-1 Reverse Transcriptase Y181C Mutant in complex with JLJ 578
Descriptor: 8-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]-4-fluorophenoxy}-6-fluoroindolizine-2-carbonitrile, MAGNESIUM ION, Reverse transcriptase/ribonuclease H, ...
Authors:Sasaki, T, Gannam, Z.T.K, Anderson, K.S, Jorgensen, W.L, Lee, W.
Deposit date:2018-06-18
Release date:2019-07-31
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.742 Å)
Cite:Molecular and cellular studies evaluating a potent 2-cyanoindolizine catechol diether NNRTI targeting wildtype and Y181C mutant HIV-1 reverse transcriptase.
Bioorg.Med.Chem.Lett., 29, 2019
6MEC
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BU of 6mec by Molmil
Structure of a group II intron retroelement after DNA integration
Descriptor: MAGNESIUM ION, Maturase reverse transcriptase, SODIUM ION, ...
Authors:Haack, D, Yan, X, Zhang, C, Hingey, J, Lyumkis, D, Baker, T.S, Toor, N.
Deposit date:2018-09-06
Release date:2019-08-14
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM Structures of a Group II Intron Reverse Splicing into DNA.
Cell, 178, 2019
6ME0
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BU of 6me0 by Molmil
Structure of a group II intron retroelement prior to DNA integration
Descriptor: MAGNESIUM ION, Maturase reverse transcriptase, SODIUM ION, ...
Authors:Haack, D, Yan, X, Zhang, C, Hingey, J, Lyumkis, D, Baker, T.S, Toor, N.
Deposit date:2018-09-05
Release date:2019-08-14
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM Structures of a Group II Intron Reverse Splicing into DNA.
Cell, 178, 2019
6ECL
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BU of 6ecl by Molmil
Crystal Structure of a 1,2,4-Triazole Allosteric RNase H Inhibitor in Complex with HIV Reverse Transcriptase
Descriptor: 1-[4-methoxy-3-[[5-methyl-4-(phenylmethyl)-1,2,4-triazol-3-yl]sulfanylmethyl]phenyl]ethanone, MANGANESE (II) ION, Reverse transcriptase/ribonuclease H
Authors:Kirby, K.A, Sarafianos, S.G.
Deposit date:2018-08-08
Release date:2019-08-21
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.385 Å)
Cite:Crystal Structure of a 1,2,4-Triazole Allosteric RNase H Inhibitor in Complex with HIV Reverse Transcriptase
To be published
6O9E
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BU of 6o9e by Molmil
Structure of HIV-1 Reverse Transcriptase in complex with DNA and INDOPY-1
Descriptor: 5-methyl-1-(4-nitrophenyl)-2-oxo-2,5-dihydro-1H-pyrido[3,2-b]indole-3-carbonitrile, AMMONIUM ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Ruiz, F.X, Hoang, A, Das, K, Arnold, E.
Deposit date:2019-03-13
Release date:2019-10-23
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis of HIV-1 Inhibition by Nucleotide-Competing Reverse Transcriptase Inhibitor INDOPY-1.
J.Med.Chem., 62, 2019
6UJX
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BU of 6ujx by Molmil
HIV-1 wild-type reverse transcriptase-DNA complex with (-)-FTC-TP
Descriptor: DNA primer, DNA template, MAGNESIUM ION, ...
Authors:Lansdon, E.B.
Deposit date:2019-10-03
Release date:2019-12-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.70451212 Å)
Cite:Elucidating molecular interactions ofL-nucleotides with HIV-1 reverse transcriptase and mechanism of M184V-caused drug resistance.
Commun Biol, 2, 2019
6UJY
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BU of 6ujy by Molmil
HIV-1 wild-type reverse transcriptase-DNA complex with (-)-3TC-TP
Descriptor: Lamivudine Triphosphate, MAGNESIUM ION, SULFATE ION, ...
Authors:Lansdon, E.B.
Deposit date:2019-10-03
Release date:2019-12-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.59456086 Å)
Cite:Elucidating molecular interactions ofL-nucleotides with HIV-1 reverse transcriptase and mechanism of M184V-caused drug resistance.
Commun Biol, 2, 2019

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