6DTX

Wildtype HIV-1 Reverse Transcriptase in complex with JLJ 578

Summary for 6DTX

• Entry DOI: 10.2210/pdb6dtx/pdb
• Related: 6DTW
• Descriptor: Reverse transcriptase/ribonuclease H, p51 RT, 8-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]-4-fluorophenoxy}-6-fluoroindolizine-2-carbonitrile, ... (4 entities in total)
• Functional Keywords: hiv-1, reverse transcriptase, inhibitor, hydrolase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Human immunodeficiency virus type 1 group M subtype B (isolate BH10); More
• Total number of polymer chains: 2
• Total formula weight: 114545.18

Authors

Sasaki, T.,Gannam, Z.T.K.,Anderson, K.S.,Jorgensen, W.L.,Lee, W. (deposition date: 2018-06-18, release date: 2019-07-31, Last modification date: 2023-10-11)

• Primary citation: Sasaki, T.,Gannam, Z.T.K.,Kudalkar, S.N.,Frey, K.M.,Lee, W.G.,Spasov, K.A.,Jorgensen, W.L.,Anderson, K.S.; Molecular and cellular studies evaluating a potent 2-cyanoindolizine catechol diether NNRTI targeting wildtype and Y181C mutant HIV-1 reverse transcriptase.; Bioorg.Med.Chem.Lett., 29:2182-2188, 2019; PubMed: 31281023; DOI: 10.1016/j.bmcl.2019.06.047

Experimental method

X-RAY DIFFRACTION (3.327 Å)