6O9E
Structure of HIV-1 Reverse Transcriptase in complex with DNA and INDOPY-1
Summary for 6O9E
| Entry DOI | 10.2210/pdb6o9e/pdb |
| Related PRD ID | PRD_900003 |
| Descriptor | Reverse transcriptase p66, TETRAETHYLENE GLYCOL, Reverse transcriptase p51, ... (11 entities in total) |
| Functional Keywords | human immunodeficiency virus 1, protein/dna, nucleotide-competing reverse transcriptase inhibitor, transferase, transferase-dna complex, transferase/dna |
| Biological source | Human immunodeficiency virus type 1 (HIV-1) More |
| Total number of polymer chains | 6 |
| Total formula weight | 254104.87 |
| Authors | Ruiz, F.X.,Hoang, A.,Das, K.,Arnold, E. (deposition date: 2019-03-13, release date: 2019-10-23, Last modification date: 2023-10-11) |
| Primary citation | Ruiz, F.X.,Hoang, A.,Das, K.,Arnold, E. Structural Basis of HIV-1 Inhibition by Nucleotide-Competing Reverse Transcriptase Inhibitor INDOPY-1. J.Med.Chem., 62:9996-10002, 2019 Cited by PubMed Abstract: HIV-1 reverse transcriptase (RT) is an essential enzyme, targeting half of approved anti-AIDS drugs. While nucleoside RT inhibitors (NRTIs) are DNA chain terminators, the nucleotide-competing RT inhibitor (NcRTI) INDOPY-1 blocks dNTP binding to RT. Lack of structural information hindered INDOPY-1 improvement. Here we report the HIV-1 RT/DNA/INDOPY-1 crystal structure, revealing a unique mode of inhibitor binding at the polymerase active site without involving catalytic metal ions. The structure may enable new strategies for developing NcRTIs. PubMed: 31603676DOI: 10.1021/acs.jmedchem.9b01289 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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