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6OUN

Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and (-)3TC-TP

Summary for 6OUN
Entry DOI10.2210/pdb6oun/pdb
DescriptorReverse transcriptase/ribonuclease H, P51 RT, DNA primer 20-mer, ... (8 entities in total)
Functional Keywordsreverse transcriptase, ternary complex, (-)3tc-tp, chain terminator, lamivudine, stereochemistry, transferase, transferase-dna complex, transferase/dna
Biological sourceHuman immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)
More
Total number of polymer chains4
Total formula weight132732.66
Authors
Bertoletti, N.,Anderson, K.S. (deposition date: 2019-05-04, release date: 2019-07-24, Last modification date: 2023-10-11)
Primary citationBertoletti, N.,Chan, A.H.,Schinazi, R.F.,Yin, Y.W.,Anderson, K.S.
Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV-1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine.
Protein Sci., 28:1664-1675, 2019
Cited by
PubMed: 31301259
DOI: 10.1002/pro.3681
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.656 Å)
Structure validation

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