6OUN
Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and (-)3TC-TP
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Reverse transcriptase/ribonuclease H | polymer | 558 | 64309.6 | 1 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) In PDB | Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) | Exoribonuclease H, p66 RT |
2 | B | P51 RT | polymer | 452 | 52748.4 | 1 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB | Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) | |
3 | P | DNA primer 20-mer | polymer | 21 | 6460.2 | 1 | synthetic construct | ||
4 | T | DNA template 27-mer | polymer | 27 | 8408.4 | 1 | synthetic construct | ||
5 | A | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
6 | A, P, T | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
7 | A | Lamivudine Triphosphate | non-polymer | 469.2 | 1 | Chemie (1RZ) | |||
8 | water | water | 18.0 | 11 | Chemie (HOH) |
Sequence modifications
A: 1 - 558 (UniProt: P03366)
B: 1 - 440 (UniProt: P03366)
PDB | External Database | Details |
---|---|---|
Arg 172 | Lys 771 | conflict |
Cys 258 | Gln 857 | engineered mutation |
Ser 280 | Cys 879 | engineered mutation |
Arg 461 | Lys 1060 | conflict |
Thr 468 | Pro 1067 | conflict |
Asp 471 | Asn 1070 | conflict |
Gln 512 | Lys 1111 | conflict |
PDB | External Database | Details |
---|---|---|
Met -11 | - | expression tag |
Gly -10 | - | expression tag |
Ser -9 | - | expression tag |
Ser -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Arg 172 | Lys 771 | conflict |
Ser 280 | Cys 879 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 131926.7 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 806.0 | |
All* | Total formula weight | 132732.7 |