6IK9

HIV-1 reverse transcriptase with Q151M/G112S/D113A/Y115F/F116Y/F160L/I159L:DNA:dGTP ternary complex

Summary for 6IK9

Entry DOI	10.2210/pdb6ik9/pdb
Descriptor	HIV-1 reverse transcriptase p66 subunit, HIV-1 reverse transcriptase p51 subunit, DNA/RNA (38-MER), ... (7 entities in total)
Functional Keywords	hiv-1, hbv, reverse transcriptase, drug resistance, drug sensitivity, entecavir, transferase-dna complex, replication, transferase/dna
Biological source	Human immunodeficiency virus 1 More
Total number of polymer chains	6
Total formula weight	256574.22
Authors	Yasutake, Y.,Hattori, S.I.,Tamura, N.,Maeda, K. (deposition date: 2018-10-15, release date: 2019-01-30, Last modification date: 2023-11-22)
Primary citation	Yasutake, Y.,Hattori, S.I.,Tamura, N.,Matsuda, K.,Kohgo, S.,Maeda, K.,Mitsuya, H. Active-site deformation in the structure of HIV-1 RT with HBV-associated septuple amino acid substitutions rationalizes the differential susceptibility of HIV-1 and HBV against 4'-modified nucleoside RT inhibitors. Biochem. Biophys. Res. Commun., 509:943-948, 2019 Cited by PubMed: 30648556 DOI: 10.1016/j.bbrc.2019.01.026 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.435 Å)

Structure validation