6E53

Structure of TERT in complex with a novel telomerase inhibitor

Summary for 6E53

• Entry DOI: 10.2210/pdb6e53/pdb
• Descriptor: Telomerase reverse transcriptase, RNA/DNA hairpin, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: telomerase, catalytic subunit, telomerase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Tribolium castaneum (red flour beetle); More
• Total number of polymer chains: 2
• Total formula weight: 78333.05

Authors

Hernandez-Sanchez, W.,Huang, W.,Plucinsky, B.,Garcia-Vazquez, N.,Berdis, A.J.,Skordalakes, E.,Taylor, D.J. (deposition date: 2018-07-19, release date: 2019-03-27, Last modification date: 2023-10-11)

• Primary citation: Hernandez-Sanchez, W.,Huang, W.,Plucinsky, B.,Garcia-Vazquez, N.,Robinson, N.J.,Schiemann, W.P.,Berdis, A.J.,Skordalakes, E.,Taylor, D.J.; A non-natural nucleotide uses a specific pocket to selectively inhibit telomerase activity.; Plos Biol., 17:e3000204-e3000204, 2019; PubMed: 30951520; DOI: 10.1371/journal.pbio.3000204

Experimental method

X-RAY DIFFRACTION (2.8 Å)