6ECL

Crystal Structure of a 1,2,4-Triazole Allosteric RNase H Inhibitor in Complex with HIV Reverse Transcriptase

Summary for 6ECL

• Entry DOI: 10.2210/pdb6ecl/pdb
• Descriptor: Reverse transcriptase/ribonuclease H, MANGANESE (II) ION, 1-[4-methoxy-3-[[5-methyl-4-(phenylmethyl)-1,2,4-triazol-3-yl]sulfanylmethyl]phenyl]ethanone, ... (5 entities in total)
• Functional Keywords: hiv-1, reverse transcriptase, rnase h, inhibitor, transferase
• Biological source: Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1); More
• Total number of polymer chains: 2
• Total formula weight: 114679.32

Authors

Kirby, K.A.,Sarafianos, S.G. (deposition date: 2018-08-08, release date: 2019-08-21, Last modification date: 2023-10-11)

• Primary citation: Kirby, K.A.,Sarafianos, S.G.; Crystal Structure of a 1,2,4-Triazole Allosteric RNase H Inhibitor in Complex with HIV Reverse Transcriptase; To be published,

Experimental method

X-RAY DIFFRACTION (2.385 Å)