7BXA
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![BU of 7bxa by Molmil](/molmil-images/mine/7bxa) | Crystal structure of PD-1 in complex with tislelizumab Fab | Descriptor: | Programmed cell death protein 1, heavy chain, light chain | Authors: | Heo, Y.S, Lee, S.H, Lim, H, Lee, H.T, Kim, Y.J, Park, E.B. | Deposit date: | 2020-04-18 | Release date: | 2020-06-10 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.32 Å) | Cite: | Crystal structure of PD-1 in complex with an antibody-drug tislelizumab used in tumor immune checkpoint therapy. Biochem.Biophys.Res.Commun., 527, 2020
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6FLC
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![BU of 6flc by Molmil](/molmil-images/mine/6flc) | 2C8 Fab bound to EDIII of DenV 2 | Descriptor: | Domain III of Dengue virus 2, GLYCEROL, Heavy chain of 2C8 Fab, ... | Authors: | Flanagan, A, Renner, M, Grimes, J.M. | Deposit date: | 2018-01-25 | Release date: | 2018-10-24 | Last modified: | 2018-10-31 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Characterization of a potent and highly unusual minimally enhancing antibody directed against dengue virus. Nat. Immunol., 19, 2018
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7OP0
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![BU of 7op0 by Molmil](/molmil-images/mine/7op0) | Crystal structure of complement C5 in complex with chemically synthesized K92 knob domain. | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5 alpha chain, ... | Authors: | Macpherson, A, van der Elsen, J.M.H, Schulze, M.E, Birtley, J.R. | Deposit date: | 2021-05-28 | Release date: | 2022-04-06 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.57 Å) | Cite: | The Chemical Synthesis of Knob Domain Antibody Fragments. Acs Chem.Biol., 16, 2021
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6ORP
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![BU of 6orp by Molmil](/molmil-images/mine/6orp) | Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch antibody Ab897NHP | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ab897NHP antibody Fab heavy chain, ... | Authors: | Abernathy, M.E, Gristick, H.B, Bjorkman, P.J. | Deposit date: | 2019-04-30 | Release date: | 2019-06-12 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques. Nature, 570, 2019
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6FLB
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![BU of 6flb by Molmil](/molmil-images/mine/6flb) | 3H5 Fab bound to EDIII of DenV 2 Xtal form 2 | Descriptor: | CHLORIDE ION, Domain III of Dengue virus 2, GLYCEROL, ... | Authors: | Flanagan, A, Renner, M, Grimes, J.M. | Deposit date: | 2018-01-25 | Release date: | 2018-10-24 | Last modified: | 2018-10-31 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Characterization of a potent and highly unusual minimally enhancing antibody directed against dengue virus. Nat. Immunol., 19, 2018
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4YC2
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![BU of 4yc2 by Molmil](/molmil-images/mine/4yc2) | |
1FJ1
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![BU of 1fj1 by Molmil](/molmil-images/mine/1fj1) | |
6VUA
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![BU of 6vua by Molmil](/molmil-images/mine/6vua) | X-ray structure of human CD38 catalytic domain with 2'-Cl-araNAD+ | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, DI(HYDROXYETHYL)ETHER, ... | Authors: | Dai, Z, Zhang, X.N, Nasertorabi, F, Han, G.W, Stevens, R.C, Zhang, Y. | Deposit date: | 2020-02-14 | Release date: | 2020-06-03 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Synthesis of site-specific antibody-drug conjugates by ADP-ribosyl cyclases. Sci Adv, 6, 2020
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7RA8
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![BU of 7ra8 by Molmil](/molmil-images/mine/7ra8) | |
7RAL
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![BU of 7ral by Molmil](/molmil-images/mine/7ral) | |
8TLM
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![BU of 8tlm by Molmil](/molmil-images/mine/8tlm) | Structure of a class A GPCR/Fab complex | Descriptor: | C-C chemokine receptor type 8, Green fluorescent protein fusion, Fab heavy chain, ... | Authors: | Sun, D, Johnson, M, Masureel, M. | Deposit date: | 2023-07-27 | Release date: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8. Nat Commun, 14, 2023
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8U1U
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![BU of 8u1u by Molmil](/molmil-images/mine/8u1u) | Structure of a class A GPCR/agonist complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, C-C motif chemokine 1,C-C chemokine receptor type 8,EGFP fusion protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Sun, D, Johnson, M, Masureel, M. | Deposit date: | 2023-09-02 | Release date: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8. Nat Commun, 14, 2023
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3RKD
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![BU of 3rkd by Molmil](/molmil-images/mine/3rkd) | |
4C83
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![BU of 4c83 by Molmil](/molmil-images/mine/4c83) | Crystal Structure of the IgG2a LPT3 in complex with an 8-sugar inner core analogue of Neisseria meningitidis | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-2)-L-glycero-alpha-D-manno-heptopyranose-(1-3)-[beta-D-glucopyranose-(1-4)]L-glycero-alpha-D-manno-heptopyranose-(1-5)-3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid, LPT3 HEAVY CHAIN, LPT3 LIGHT CHAIN, ... | Authors: | Parker, M.J, Gomery, K, Richard, G, Mackenzie, C.R, Cox, A.D, Richards, J.C, Evans, S.V. | Deposit date: | 2013-09-29 | Release date: | 2014-02-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Structural Basis for Selective Cross-Reactivity in a Bactericidal Antibody Against Inner Core Lipooligosaccharide from Neisseria Meningitidis. Glycobiology, 24, 2014
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1ADQ
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7EFR
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![BU of 7efr by Molmil](/molmil-images/mine/7efr) | Structure of SARS-CoV-2 spike receptor-binding domain in complex with high affinity ACE2 mutant (T27W,N330Y) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, Spike glycoprotein | Authors: | Lu, G.W, Ye, F, Lin, X. | Deposit date: | 2021-03-23 | Release date: | 2021-11-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.494 Å) | Cite: | S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis. Signal Transduct Target Ther, 6, 2021
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7EFP
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![BU of 7efp by Molmil](/molmil-images/mine/7efp) | Structure of SARS-CoV-2 spike receptor-binding domain in complex with high affinity ACE2 mutant (S19W,N330Y) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, Spike glycoprotein | Authors: | Lu, G.W, Ye, F, Lin, X. | Deposit date: | 2021-03-22 | Release date: | 2021-11-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.698 Å) | Cite: | S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis. Signal Transduct Target Ther, 6, 2021
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1TFH
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![BU of 1tfh by Molmil](/molmil-images/mine/1tfh) | EXTRACELLULAR DOMAIN OF HUMAN TISSUE FACTOR | Descriptor: | HUMAN TISSUE FACTOR | Authors: | Huang, M, Syed, R, Stura, E.A, Stone, M.J, Stefanko, R.S, Ruf, W, Edgington, T.S, Wilson, I.A. | Deposit date: | 1997-04-10 | Release date: | 1998-02-25 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The mechanism of an inhibitory antibody on TF-initiated blood coagulation revealed by the crystal structures of human tissue factor, Fab 5G9 and TF.G9 complex. J.Mol.Biol., 275, 1998
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5XHV
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![BU of 5xhv by Molmil](/molmil-images/mine/5xhv) | Crystal Structure Of Fab S40 In Complex With Influenza Hemagglutinin, HA1 subunit. | Descriptor: | Hemagglutinin, S40 heavy chain, S40 light chain | Authors: | Lee, C.C, Wang, A.H.J, Yu, C.M, Yang, A.S. | Deposit date: | 2017-04-24 | Release date: | 2017-11-15 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.35 Å) | Cite: | High throughput discovery of influenza virus neutralizing antibodies from phage-displayed synthetic antibody libraries. Sci Rep, 7, 2017
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8QYA
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6UDK
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![BU of 6udk by Molmil](/molmil-images/mine/6udk) | HIV-1 bNAb 1-55 in complex with modified BG505 SOSIP-based immunogen RC1 and 10-1074 | Descriptor: | 1-55 Fab Heavy Chain, 1-55 Fab Light Chain, 10-1074 Fab Heavy Chain, ... | Authors: | Abernathy, M.E, Barnes, C.O, Gristick, H.B, Bjorkman, P.J. | Deposit date: | 2019-09-19 | Release date: | 2020-01-29 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody. Cell, 180, 2020
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6UDJ
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![BU of 6udj by Molmil](/molmil-images/mine/6udj) | HIV-1 bNAb 1-18 in complex with BG505 SOSIP.664 and 10-1074 | Descriptor: | 1-18 Fab Heavy Chain, 1-18 Fab Light Chain, 10-1074 Fab Heavy Chain, ... | Authors: | Abernathy, M.E, Barnes, C.O, Gristick, H.B, Bjorkman, P.J. | Deposit date: | 2019-09-19 | Release date: | 2020-01-29 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody. Cell, 180, 2020
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8ATH
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![BU of 8ath by Molmil](/molmil-images/mine/8ath) | CRYSTAL STRUCTURE OF LAMP1 IN COMPLEX WITH FAB-B. | Descriptor: | Fab B Heavy Chain, Fab B Light Chain, Lysosome-associated membrane glycoprotein 1 | Authors: | Mathieu, M, Dupuy, A. | Deposit date: | 2022-08-23 | Release date: | 2023-03-01 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.366 Å) | Cite: | Deciphering cross-species reactivity of LAMP-1 antibodies using deep mutational epitope mapping and AlphaFold. Mabs, 15, 2023
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4QGT
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![BU of 4qgt by Molmil](/molmil-images/mine/4qgt) | The Crystal Structure of Human IgG Fc Domain with Enhanced Aromatic Sequon | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | Authors: | Kong, L, Connelly, S.C, Wilson, I.A. | Deposit date: | 2014-05-25 | Release date: | 2015-04-08 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.99 Å) | Cite: | Stabilizing the CH2 Domain of an Antibody by Engineering in an Enhanced Aromatic Sequon. Acs Chem.Biol., 11, 2016
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5UEL
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![BU of 5uel by Molmil](/molmil-images/mine/5uel) | Crystal structure of 354NC102 Fab | Descriptor: | 354NC102 Fab Heavy Chain, 354NC102 Fab Light Chain, SULFATE ION | Authors: | Sievers, S.A, Gristick, H.B, Bjorkman, P.J. | Deposit date: | 2017-01-02 | Release date: | 2017-02-01 | Last modified: | 2022-04-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller. Sci Transl Med, 9, 2017
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