4QGT

The Crystal Structure of Human IgG Fc Domain with Enhanced Aromatic Sequon

Summary for 4QGT

• Entry DOI: 10.2210/pdb4qgt/pdb
• Related: 2WAH 3AVE 4BM7
• Descriptor: Hepatitis B virus receptor binding protein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: igg1, immunoglobulin-like beta-sandwich, immune system
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 54972.86

Authors

Kong, L.,Connelly, S.C.,Wilson, I.A. (deposition date: 2014-05-25, release date: 2015-04-08, Last modification date: 2023-09-20)

• Primary citation: Chen, W.,Kong, L.,Connelly, S.,Dendle, J.M.,Liu, Y.,Wilson, I.A.,Powers, E.T.,Kelly, J.W.; Stabilizing the CH2 Domain of an Antibody by Engineering in an Enhanced Aromatic Sequon.; Acs Chem.Biol., 11:1852-1861, 2016; PubMed: 27128252; DOI: 10.1021/acschembio.5b01035

Experimental method

X-RAY DIFFRACTION (2.99 Å)