4BM7

Crystal Structure of IgG Fc F241A mutant with native glycosylation

Summary for 4BM7

Entry DOI	10.2210/pdb4bm7/pdb
Descriptor	IG GAMMA-1 CHAIN C REGION, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	immune system, glycan
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	2
Total formula weight	53854.99
Authors	Yu, X.,Baruah, K.,Harvey, D.J.,Vasiljevic, S.,Alonzi, D.S.,Song, B.,Higgins, M.K.,Bowden, T.A.,Crispin, M.,Scanlan, C.N. (deposition date: 2013-05-07, release date: 2013-07-03, Last modification date: 2023-12-20)
Primary citation	Yu, X.,Baruah, K.,Harvey, D.J.,Vasiljevic, S.,Alonzi, D.S.,Song, B.,Higgins, M.K.,Bowden, T.A.,Scanlan, C.N.,Crispin, M. Engineering Hydrophobic Protein-Carbohydrate Interactions to Fine-Tune Monoclonal Antibodies. J.Am.Chem.Soc., 135:9723-, 2013 Cited by PubMed: 23745692 DOI: 10.1021/JA4014375 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation