4BM7
Crystal Structure of IgG Fc F241A mutant with native glycosylation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | IG GAMMA-1 CHAIN C REGION | polymer | 233 | 26279.7 | 2 | UniProt (P01857) Pfam (PF07654) | HOMO SAPIENS (HUMAN) | |
| 2 | C (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1260.2 | 1 | In PDB GlyTouCan (G20449BJ) | |||
| 3 | D (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | E, F (A, B) | water | water | 18.0 | 297 | Chemie (HOH) |
Sequence modifications
A, B: 223 - 446 (UniProt: P01857)
| PDB | External Database | Details |
|---|---|---|
| Gly 222 | - | expression tag |
| Thr 447 | - | expression tag |
| Lys 448 | - | expression tag |
| His 449 | - | expression tag |
| His 450 | - | expression tag |
| His 451 | - | expression tag |
| His 452 | - | expression tag |
| His 453 | - | expression tag |
| His 454 | - | expression tag |
| Ala 241 | Phe 124 | engineered mutation |
| Glu 356 | Asp 239 | variant |
| Met 358 | Leu 241 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 52559.4 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 1260.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 35.5 | |
| All* | Total formula weight | 53855.0 |
