6UDK

HIV-1 bNAb 1-55 in complex with modified BG505 SOSIP-based immunogen RC1 and 10-1074

Summary for 6UDK

• Entry DOI: 10.2210/pdb6udk/pdb
• Related: 6ORN
• EMDB information: 20175 20739 20740
• Descriptor: RC1 variant of HIV-1 Env glycoprotein gp120, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (13 entities in total)
• Functional Keywords: hiv-1 broadly neutralizing antibody, bnab, env trimer, cryo-em, rc1, cd4-binding site, viral protein-immune system complex, viral protein/immune system
• Biological source: Human immunodeficiency virus 1 (HIV-1); More
• Total number of polymer chains: 18
• Total formula weight: 540021.82

Authors

Abernathy, M.E.,Barnes, C.O.,Gristick, H.B.,Bjorkman, P.J. (deposition date: 2019-09-19, release date: 2020-01-29, Last modification date: 2020-07-29)

• Primary citation: Schommers, P.,Gruell, H.,Abernathy, M.E.,Tran, M.K.,Dingens, A.S.,Gristick, H.B.,Barnes, C.O.,Schoofs, T.,Schlotz, M.,Vanshylla, K.,Kreer, C.,Weiland, D.,Holtick, U.,Scheid, C.,Valter, M.M.,van Gils, M.J.,Sanders, R.W.,Vehreschild, J.J.,Cornely, O.A.,Lehmann, C.,Fatkenheuer, G.,Seaman, M.S.,Bloom, J.D.,Bjorkman, P.J.,Klein, F.; Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody.; Cell, 180:471-, 2020; PubMed: 32004464; DOI: 10.1016/j.cell.2020.01.010

Experimental method

ELECTRON MICROSCOPY (3.9 Å)