6ORN

Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch bNAb 10-1074

Summary for 6ORN

EMDB information20175
DescriptorRC1 variant of HIV-1 Env glycoprotein gp41, RC1 variant of HIV-1 Env glycoprotein gp120, 10-1074 antibody Fab heavy chain, ... (7 entities in total)
Functional Keywordshiv-1 broadly-neutralizing antibody, env trimer structure, v3-glycan patch, cryo-em, rc1, immunogen design, antiviral protein-immune system complex, antiviral protein, viral protein-immune system complex, viral protein/immune system
Biological sourceHuman immunodeficiency virus 1
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Total number of polymer chains12
Total molecular weight381530.51
Authors
Abernathy, M.E.,Gristick, H.B.,Bjorkman, P.J. (deposition date: 2019-04-30, release date: 2019-06-12, Last modification date: 2019-12-18)
Primary citation
Escolano, A.,Gristick, H.B.,Abernathy, M.E.,Merkenschlager, J.,Gautam, R.,Oliveira, T.Y.,Pai, J.,West Jr., A.P.,Barnes, C.O.,Cohen, A.A.,Wang, H.,Golijanin, J.,Yost, D.,Keeffe, J.R.,Wang, Z.,Zhao, P.,Yao, K.H.,Bauer, J.,Nogueira, L.,Gao, H.,Voll, A.V.,Montefiori, D.C.,Seaman, M.S.,Gazumyan, A.,Silva, M.,McGuire, A.T.,Stamatatos, L.,Irvine, D.J.,Wells, L.,Martin, M.A.,Bjorkman, P.J.,Nussenzweig, M.C.
Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques.
Nature, 570:468-473, 2019
PubMed: 31142836 (PDB entries with the same primary citation)
DOI: 10.1038/s41586-019-1250-z
MImport into Mendeley
Experimental method
ELECTRON MICROSCOPY
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Structure validation

ClashscoreRamachandran outliersSidechain outliers4 0.2% 1.2%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
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