6UDK

HIV-1 bNAb 1-55 in complex with modified BG505 SOSIP-based immunogen RC1 and 10-1074

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	G, K, R	RC1 variant of HIV-1 Env glycoprotein gp120	polymer	481	54149.6	3	Pfam (PF00516) UniProt (by SIFTS) (Q2N0S6) In PDB	Human immunodeficiency virus 1 (HIV-1)
2	A, F, O	10-1074 Fab Heavy Chain	polymer	238	25661.7	3	UniProt (S6B2B6) Pfam (PF07686) Pfam (PF07654) In PDB	Homo sapiens (Human)
3	B, I, P	10-1074 Fab Light Chain	polymer	214	23180.8	3	UniProt (Q8N355) Pfam (PF07686) Pfam (PF07654) In PDB	Homo sapiens (Human)
4	M, D, H	1-55 Fab Heavy Chain	polymer	262	28804.3	3	UniProt (S6C4S0) Pfam (PF07686) Pfam (PF07654) In PDB	Homo sapiens (Human)
5	N, E, L	1-55 Fab Light Chain	polymer	234	25288.3	3	UniProt (Q6PJF2) Pfam (PF07686) Pfam (PF07654) In PDB	Homo sapiens (Human)
6	C, J, Q	RC1 variant of HIV-1 Env glycoprotein gp41	polymer	153	17134.3	3	Pfam (PF00517) UniProt (by SIFTS) (Q2N0S6) In PDB	Human immunodeficiency virus 1 (HIV-1)
7	b, c, f, g, S...	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	7	In PDB GlyTouCan (G42666HT)
8	d, T	alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1073.0	2	In PDB GlyTouCan (G56014GC)
9	U, Z	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
10	a, V	alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1397.2	2	In PDB GlyTouCan (G80966KZ)
11	Y	alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1235.1	1	In PDB GlyTouCan (G07617FP)
12	e	alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1073.0	1	In PDB GlyTouCan (G34442SS)
13	R, G, K	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	27	Chemie (NAG)

Sequence modifications

A, F, O: 1 - 108 (PDB: 6UDK)
A, F, O: 109 - 219 (UniProt: S6B2B6)
B, I, P: 6 - 103 (PDB: 6UDK)
B, I, P: 104 - 213 (UniProt: Q8N355)
M, D, H: -18 - 110 (PDB: 6UDK)
M, D, H: 111 - 220 (UniProt: S6C4S0)

PDB	External Database	Details
His 221	-	expression tag
His 222	-	expression tag
His 223	-	expression tag
His 224	-	expression tag
His 225	-	expression tag

N, E, L: -18 - 100 (PDB: 6UDK)
N, E, L: 101 - 214 (UniProt: Q6PJF2)

Contents of the asymmetric unit

Polymers	Number of chains	18
	Total formula weight	522656.8
Branched	Number of molecules	15
	Total formula weight	11392.4
Non-Polymers*	Number of molecules	27
	Total formula weight	5972.6
All*	Total formula weight	540021.8

*Water molecules are not included.