7MEX
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![BU of 7mex by Molmil](/molmil-images/mine/7mex) | Structure of yeast Ubr1 in complex with Ubc2 and N-degron | Descriptor: | E3 ubiquitin-protein ligase UBR1, N-degron, Ubiquitin, ... | Authors: | Pan, M, Zheng, Q, Wang, T, Liang, L, Yu, Y, Liu, L, Zhao, M. | Deposit date: | 2021-04-08 | Release date: | 2021-11-24 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | Structural insights into Ubr1-mediated N-degron polyubiquitination. Nature, 600, 2021
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5UDH
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![BU of 5udh by Molmil](/molmil-images/mine/5udh) | HHARI/ARIH1-UBCH7~Ubiquitin | Descriptor: | E3 ubiquitin-protein ligase ARIH1, Ubiquitin C variant, Ubiquitin-conjugating enzyme E2 L3, ... | Authors: | Miller, D.J, Schulman, B.A. | Deposit date: | 2016-12-27 | Release date: | 2017-06-14 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3.24 Å) | Cite: | Structural Studies of HHARI/UbcH7Ub Reveal Unique E2Ub Conformational Restriction by RBR RING1. Structure, 25, 2017
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5TTE
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![BU of 5tte by Molmil](/molmil-images/mine/5tte) | Crystal Structure of an RBR E3 ubiquitin ligase in complex with an E2-Ub thioester intermediate mimic | Descriptor: | E3 ubiquitin-protein ligase ARIH1, Ubiquitin-conjugating enzyme E2 L3, ZINC ION, ... | Authors: | Yuan, L, Lv, Z, Olsen, S.K. | Deposit date: | 2016-11-03 | Release date: | 2017-08-23 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.501 Å) | Cite: | Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI. Nat Commun, 8, 2017
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5ULH
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![BU of 5ulh by Molmil](/molmil-images/mine/5ulh) | |
5T6R
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![BU of 5t6r by Molmil](/molmil-images/mine/5t6r) | Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome biogenesis: 60S-Nmd3 Complex | Descriptor: | 25S Ribosomal RNA, 5.8S Ribosomal RNA, 5S Ribosomal RNA, ... | Authors: | Malyutin, A.G, Musalgaonkar, S, Patchett, S, Frank, J, Johnson, A.W. | Deposit date: | 2016-09-01 | Release date: | 2017-02-08 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome biogenesis. EMBO J., 36, 2017
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5TGM
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![BU of 5tgm by Molmil](/molmil-images/mine/5tgm) | Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 3'-amino-3'-deoxyadenosine 5'-(dihydrogen phosphate), ... | Authors: | Melnikov, S, Mailliot, J, Yusupov, M. | Deposit date: | 2016-09-28 | Release date: | 2017-01-18 | Last modified: | 2022-12-07 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Molecular insights into protein synthesis with proline residues. EMBO Rep., 17, 2016
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5T2A
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![BU of 5t2a by Molmil](/molmil-images/mine/5t2a) | CryoEM structure of the Leishmania donovani 80S ribosome at 2.9 Angstrom resolution | Descriptor: | 18S rRNA, 5.8S rRNA, 5S rRNA, ... | Authors: | Zhang, X, Lai, M, Zhou, Z.H. | Deposit date: | 2016-08-23 | Release date: | 2017-01-25 | Last modified: | 2018-07-18 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes. Nat Commun, 7, 2016
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5T62
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![BU of 5t62 by Molmil](/molmil-images/mine/5t62) | Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome biogenesis: 60S-Nmd3-Tif6-Lsg1 Complex | Descriptor: | 25S Ribosomal RNA, 5.8S Ribosomal RNA, 5S Ribosomal RNA, ... | Authors: | Malyutin, A.G, Musalgaonkar, S, Patchett, S, Frank, J, Johnson, A.W. | Deposit date: | 2016-09-01 | Release date: | 2017-02-08 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome biogenesis. EMBO J., 36, 2017
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5T2C
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![BU of 5t2c by Molmil](/molmil-images/mine/5t2c) | CryoEM structure of the human ribosome at 3.6 Angstrom resolution | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | Authors: | Zhang, X, Lai, M, Zhou, Z.H. | Deposit date: | 2016-08-23 | Release date: | 2017-01-25 | Last modified: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes. Nat Commun, 7, 2016
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5TUT
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![BU of 5tut by Molmil](/molmil-images/mine/5tut) | |
5ULF
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![BU of 5ulf by Molmil](/molmil-images/mine/5ulf) | |
5VEY
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![BU of 5vey by Molmil](/molmil-images/mine/5vey) | Solution NMR structure of histone H2A-H2B mono-ubiquitylated at H2A Lys15 in complex with RNF169 (653-708) | Descriptor: | E3 ubiquitin-protein ligase RNF169, Histone H2B type 1-J,Histone H2A type 1-B/E, Polyubiquitin-B | Authors: | Hu, Q, Botuyan, M.V, Cui, G, Mer, G. | Deposit date: | 2017-04-06 | Release date: | 2017-05-17 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Mechanisms of Ubiquitin-Nucleosome Recognition and Regulation of 53BP1 Chromatin Recruitment by RNF168/169 and RAD18. Mol. Cell, 66, 2017
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5UMD
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![BU of 5umd by Molmil](/molmil-images/mine/5umd) | Structure of the Plasmodium falciparum 80S ribosome bound to the antimalarial drug mefloquine | Descriptor: | 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | Authors: | Wong, W, Bai, X.-C, Brown, A, Scheres, S, Baum, J. | Deposit date: | 2017-01-27 | Release date: | 2017-03-01 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis. Nat Microbiol, 2, 2017
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5ULK
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![BU of 5ulk by Molmil](/molmil-images/mine/5ulk) | |
5VYC
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![BU of 5vyc by Molmil](/molmil-images/mine/5vyc) | Crystal structure of the human 40S ribosomal subunit in complex with DENR-MCT-1. | Descriptor: | 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S12, ... | Authors: | Lomakin, I.B, Stolboushkina, E.A, Vaidya, A.T, Garber, M.B, Dmitriev, S.E, Steitz, T.A. | Deposit date: | 2017-05-24 | Release date: | 2017-07-19 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (6 Å) | Cite: | Crystal Structure of the Human Ribosome in Complex with DENR-MCT-1. Cell Rep, 20, 2017
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6ZXE
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![BU of 6zxe by Molmil](/molmil-images/mine/6zxe) | Cryo-EM structure of a late human pre-40S ribosomal subunit - State F2 | Descriptor: | 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S12, ... | Authors: | Ameismeier, M, Zemp, I, van den Heuvel, J, Thoms, M, Berninghausen, O, Kutay, U, Beckmann, R. | Deposit date: | 2020-07-29 | Release date: | 2020-12-02 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis for the final steps of human 40S ribosome maturation. Nature, 587, 2020
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5L9T
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![BU of 5l9t by Molmil](/molmil-images/mine/5l9t) | Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with E2 UBE2S poised for polyubiquitination where UBE2S, APC2, and APC11 are modeled into low resolution density | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | Authors: | Brown, N.G, VanderLinden, R, Dube, P, Haselbach, D, Peters, J.M, Stark, H, Schulman, B.A. | Deposit date: | 2016-06-11 | Release date: | 2016-10-26 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (6.4 Å) | Cite: | Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C. Cell, 165, 2016
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7ABG
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![BU of 7abg by Molmil](/molmil-images/mine/7abg) | Human pre-Bact-1 spliceosome | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, Cell division cycle 5-like protein, ... | Authors: | Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R. | Deposit date: | 2020-09-07 | Release date: | 2020-12-23 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (7.8 Å) | Cite: | Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science, 370, 2020
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7A09
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![BU of 7a09 by Molmil](/molmil-images/mine/7a09) | Structure of a human ABCE1-bound 43S pre-initiation complex - State III | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | Authors: | Kratzat, H, Mackens-Kiani, T, Ameismeier, A, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R. | Deposit date: | 2020-08-07 | Release date: | 2020-10-14 | Last modified: | 2021-01-13 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | A structural inventory of native ribosomal ABCE1-43S pre-initiation complexes. Embo J., 40, 2021
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7ABI
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![BU of 7abi by Molmil](/molmil-images/mine/7abi) | Human pre-Bact-2 spliceosome | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Beta-catenin-like protein 1, ... | Authors: | Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R. | Deposit date: | 2020-09-07 | Release date: | 2021-02-10 | Method: | ELECTRON MICROSCOPY (8 Å) | Cite: | Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science, 370, 2020
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5LKS
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![BU of 5lks by Molmil](/molmil-images/mine/5lks) | Structure-function insights reveal the human ribosome as a cancer target for antibiotics | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ... | Authors: | Myasnikov, A.G, Natchiar, S.K, Nebout, M, Hazemann, I, Imbert, V, Khatter, H, Peyron, J.-F, Klaholz, B.P. | Deposit date: | 2016-07-23 | Release date: | 2017-04-26 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structure-function insights reveal the human ribosome as a cancer target for antibiotics. Nat Commun, 7, 2016
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6ZUO
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![BU of 6zuo by Molmil](/molmil-images/mine/6zuo) | Human RIO1(kd)-StHA late pre-40S particle, structural state A (pre 18S rRNA cleavage) | Descriptor: | 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S12, ... | Authors: | Plassart, L, Shayan, R, Plisson-Chastang, C. | Deposit date: | 2020-07-23 | Release date: | 2021-05-12 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | The final step of 40S ribosomal subunit maturation is controlled by a dual key lock. Elife, 10, 2021
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6ZV6
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![BU of 6zv6 by Molmil](/molmil-images/mine/6zv6) | Human RIO1(kd)-StHA late pre-40S particle, structural state B (post 18S rRNA cleavage) | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | Authors: | Plassart, L, Shayan, R, Plisson-Chastang, C. | Deposit date: | 2020-07-24 | Release date: | 2021-05-12 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | The final step of 40S ribosomal subunit maturation is controlled by a dual key lock. Elife, 10, 2021
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5LZU
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![BU of 5lzu by Molmil](/molmil-images/mine/5lzu) | Structure of the mammalian ribosomal termination complex with accommodated eRF1 | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... | Authors: | Shao, S, Murray, J, Brown, A, Taunton, J, Ramakrishnan, V, Hegde, R.S. | Deposit date: | 2016-10-02 | Release date: | 2016-11-30 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.75 Å) | Cite: | Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes. Cell, 167, 2016
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6Y53
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![BU of 6y53 by Molmil](/molmil-images/mine/6y53) | human 17S U2 snRNP low resolution part | Descriptor: | HIV Tat-specific factor 1, Probable ATP-dependent RNA helicase DDX46, Small nuclear ribonucleoprotein E, ... | Authors: | Zhang, Z, Will, C.L, Bertram, K, Luehrmann, R, Stark, H. | Deposit date: | 2020-02-24 | Release date: | 2020-06-17 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (7.1 Å) | Cite: | Molecular architecture of the human 17S U2 snRNP. Nature, 583, 2020
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