5T62

Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome biogenesis: 60S-Nmd3-Tif6-Lsg1 Complex

This is a large structure.

Summary for 5T62

Related5T6R
EMDB information8362 8368
DescriptorEukaryotic translation initiation factor 6, 25S Ribosomal RNA, 5S Ribosomal RNA, ... (51 entities in total)
Functional Keywordsribosome biogenesis, 60s, nmd3, lsg1, tif6, cryo-em, ribosome
Biological sourceSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
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Total number of polymer chains47
Total molecular weight2110893.6
Authors
Malyutin, A.G.,Musalgaonkar, S.,Patchett, S.,Frank, J.,Johnson, A.W. (deposition date: 2016-09-01, release date: 2017-02-08, Last modification date: 2018-07-18)
Primary citation
Malyutin, A.G.,Musalgaonkar, S.,Patchett, S.,Frank, J.,Johnson, A.W.
Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome biogenesis.
EMBO J., 36:854-868, 2017
PubMed: 28179369 (PDB entries with the same primary citation)
DOI: 10.15252/embj.201696012
MImport into Mendeley
Experimental method
ELECTRON MICROSCOPY (3.3 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRNA backbone22.2%6.6%0.39MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures

More Asymmetric unit images

Molmil generated image of 5t62
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Molmil generated image of 5t62
rotated about x axis by 90°
Molmil generated image of 5t62
rotated about y axis by 90°
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