Structure of the Plasmodium falciparum 80S ribosome bound to the antimalarial drug mefloquine

This is a large structure.

Summary for 5UMD

EMDB information8576
Descriptor28S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ... (48 entities in total)
Functional Keywordsribosome, protein synthesis, antimalarial
Biological sourcePlasmodium falciparum 3D7
Total number of polymer chains45
Total molecular weight2136615.67
Wong, W.,Bai, X.-C.,Brown, A.,Scheres, S.,Baum, J. (deposition date: 2017-01-27, release date: 2017-03-01, Last modification date: 2019-12-11)
Primary citation
Wong, W.,Bai, X.C.,Sleebs, B.E.,Triglia, T.,Brown, A.,Thompson, J.K.,Jackson, K.E.,Hanssen, E.,Marapana, D.S.,Fernandez, I.S.,Ralph, S.A.,Cowman, A.F.,Scheres, S.H.,Baum, J.
Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis.
Nat Microbiol, 2:17031-17031, 2017
PubMed: 28288098 (PDB entries with the same primary citation)
DOI: 10.1038/nmicrobiol.2017.31
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliersRNA backbone13 2.5% 8.6% 0.44MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
Download full validation reportDownload