5UMD

Structure of the Plasmodium falciparum 80S ribosome bound to the antimalarial drug mefloquine

This is a non-PDB format compatible entry.

Summary for 5UMD

• Entry DOI: 10.2210/pdb5umd/pdb
• EMDB information: 8576
• Descriptor: 28S ribosomal RNA, 60S ribosomal protein L7-3, putative, 60S ribosomal protein L13, putative, ... (48 entities in total)
• Functional Keywords: ribosome, protein synthesis, antimalarial
• Biological source: Plasmodium falciparum 3D7; More
• Total number of polymer chains: 45
• Total formula weight: 2136615.67

Authors

Wong, W.,Bai, X.-C.,Brown, A.,Scheres, S.,Baum, J. (deposition date: 2017-01-27, release date: 2017-03-01, Last modification date: 2019-12-11)

• Primary citation: Wong, W.,Bai, X.C.,Sleebs, B.E.,Triglia, T.,Brown, A.,Thompson, J.K.,Jackson, K.E.,Hanssen, E.,Marapana, D.S.,Fernandez, I.S.,Ralph, S.A.,Cowman, A.F.,Scheres, S.H.,Baum, J.; Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis.; Nat Microbiol, 2:17031-17031, 2017; PubMed: 28288098; DOI: 10.1038/nmicrobiol.2017.31

Experimental method

ELECTRON MICROSCOPY (3.2 Å)