5UMD
Structure of the Plasmodium falciparum 80S ribosome bound to the antimalarial drug mefloquine
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 28S ribosomal RNA | polymer | 3788 | 1216212.1 | 1 | GenBank (1013064538) | Plasmodium falciparum 3D7 | |
| 2 | B (B) | 5S ribosomal RNA | polymer | 119 | 38410.9 | 1 | GenBank (1016052399) | Plasmodium falciparum 3D7 | |
| 3 | C (C) | 5.8S ribosomal RNA | polymer | 159 | 51206.5 | 1 | GenBank (1013064403) | Plasmodium falciparum 3D7 | |
| 4 | D (D) | 60S ribosomal protein L2 | polymer | 260 | 28065.0 | 1 | UniProt (Q8I3T9) Pfam (PF00181) Pfam (PF03947) | Plasmodium falciparum 3D7 | |
| 5 | E (E) | 60S ribosomal protein L3 | polymer | 386 | 44318.2 | 1 | UniProt (Q8IJC6) Pfam (PF00297) | Plasmodium falciparum 3D7 | 60S ribosomal protein L3,putative |
| 6 | F (F) | 60S ribosomal protein L4 | polymer | 411 | 46311.7 | 1 | UniProt (Q8I431) Pfam (PF00573) Pfam (PF14374) | Plasmodium falciparum 3D7 | |
| 7 | G (G) | 60S ribosomal protein L11a, putative | polymer | 173 | 20268.7 | 1 | UniProt (Q8IBQ6) Pfam (PF00281) Pfam (PF00673) | Plasmodium falciparum 3D7 | |
| 8 | H (H) | 60S ribosomal protein L6, putative | polymer | 190 | 21638.6 | 1 | UniProt (Q8IE85) Pfam (PF00347) | Plasmodium falciparum 3D7 | |
| 9 | I (I) | 60S ribosomal protein L6-2, putative | polymer | 221 | 25587.6 | 1 | UniProt (Q8IDV1) | Plasmodium falciparum 3D7 | |
| 10 | J (J) | 60S ribosomal protein L7-3, putative | polymer | 283 | 32760.5 | 1 | UniProt (Q8ILL2) Pfam (PF01248) | Plasmodium falciparum 3D7 | |
| 11 | K (K) | 60S ribosomal protein L13, putative | polymer | 202 | 23805.3 | 1 | UniProt (Q8IJZ7) Pfam (PF00572) | Plasmodium falciparum 3D7 | |
| 12 | L (L) | 60S ribosomal protein L13 | polymer | 215 | 25454.1 | 1 | UniProt (Q8IAX6) Pfam (PF01294) | Plasmodium falciparum 3D7 | |
| 13 | M (M) | 60S ribosomal protein L23, putative | polymer | 139 | 15015.7 | 1 | UniProt (Q8IE09) Pfam (PF00238) | Plasmodium falciparum 3D7 | |
| 14 | N (N) | 60S ribosomal protein L14, putative | polymer | 165 | 19340.4 | 1 | UniProt (Q8ILE8) Pfam (PF01929) | Plasmodium falciparum 3D7 | |
| 15 | O (O) | 60S ribosomal protein L27a, putative | polymer | 148 | 16765.8 | 1 | UniProt (C6KT23) Pfam (PF00828) | Plasmodium falciparum 3D7 | |
| 16 | P (P) | Ribosomal protein L15 | polymer | 205 | 24197.7 | 1 | UniProt (C0H4A6) Pfam (PF00827) | Plasmodium falciparum 3D7 | |
| 17 | Q (Q) | 60S ribosomal protein L10, putative | polymer | 219 | 25265.5 | 1 | UniProt (Q8ILV2) Pfam (PF00252) | Plasmodium falciparum 3D7 | |
| 18 | R (R) | 60S ribosomal protein L5, putative | polymer | 294 | 34067.4 | 1 | UniProt (Q8ILL3) Pfam (PF17144) Pfam (PF14204) | Plasmodium falciparum 3D7 | |
| 19 | S (S) | 60S ribosomal protein L18-2, putative | polymer | 187 | 21508.8 | 1 | UniProt (C0H5G3) Pfam (PF17135) | Plasmodium falciparum 3D7 | |
| 20 | T (T) | 60S ribosomal protein L19 | polymer | 182 | 21641.1 | 1 | UniProt (C6KSY6) Pfam (PF01280) | Plasmodium falciparum 3D7 | |
| 21 | U (U) | 60S ribosomal protein L18a | polymer | 184 | 21793.6 | 1 | UniProt (Q8IDS6) Pfam (PF01775) | Plasmodium falciparum 3D7 | |
| 22 | V (V) | 60S ribosomal protein L21 | polymer | 161 | 18840.2 | 1 | UniProt (Q8ILK3) Pfam (PF01157) | Plasmodium falciparum 3D7 | 60S ribosomal protein L21e,putative |
| 23 | W (W) | 60S ribosomal protein L17, putative | polymer | 203 | 23469.9 | 1 | UniProt (Q8IDI5) Pfam (PF00237) | Plasmodium falciparum 3D7 | |
| 24 | X (X) | 60S ribosomal protein L22, putative | polymer | 139 | 16422.9 | 1 | UniProt (Q8IB51) Pfam (PF01776) | Plasmodium falciparum 3D7 | |
| 25 | Y (Y) | 60S ribosomal protein L23 | polymer | 190 | 22152.7 | 1 | UniProt (Q8IE82) Pfam (PF03939) Pfam (PF00276) | Plasmodium falciparum 3D7 | |
| 26 | Z (Z) | 60S ribosomal protein L26, putative | polymer | 126 | 14855.7 | 1 | UniProt (O77364) Pfam (PF16906) Pfam (PF00467) | Plasmodium falciparum 3D7 | |
| 27 | AA (0) | 60S ribosomal protein L24, putative | polymer | 162 | 19295.9 | 1 | UniProt (Q8IEM3) Pfam (PF01246) | Plasmodium falciparum 3D7 | |
| 28 | BA (1) | 60S ribosomal protein L27 | polymer | 146 | 16785.2 | 1 | UniProt (Q8IKM5) Pfam (PF01777) | Plasmodium falciparum 3D7 | 60S ribosomal protein L27,putative |
| 29 | CA (2) | 60S ribosomal protein L28 | polymer | 127 | 14437.8 | 1 | UniProt (Q8IHU0) Pfam (PF01778) | Plasmodium falciparum 3D7 | 60S ribosomal protein L28,putative |
| 30 | DA (3) | 60S ribosomal protein L35, putative | polymer | 124 | 14787.8 | 1 | UniProt (Q8IIB4) Pfam (PF00831) | Plasmodium falciparum 3D7 | |
| 31 | EA (4) | 60S ribosomal protein L29, putative | polymer | 67 | 8041.6 | 1 | UniProt (C6S3J6) Pfam (PF01779) | Plasmodium falciparum 3D7 | Ribosomal protein L29,putative |
| 32 | FA (5) | 60S ribosomal protein L7, putative | polymer | 257 | 30593.2 | 1 | UniProt (O97250) Pfam (PF08079) Pfam (PF00327) | Plasmodium falciparum 3D7 | |
| 33 | GA (6) | 60S ribosomal protein L30e, putative | polymer | 108 | 11794.8 | 1 | UniProt (Q8IJK8) Pfam (PF01248) | Plasmodium falciparum 3D7 | |
| 34 | HA (7) | 60S ribosomal protein L31 | polymer | 120 | 14099.9 | 1 | UniProt (Q8I463) Pfam (PF01198) | Plasmodium falciparum 3D7 | |
| 35 | IA (8) | 60S ribosomal protein L32 | polymer | 131 | 15565.8 | 1 | UniProt (Q8I3B0) Pfam (PF01655) | Plasmodium falciparum 3D7 | |
| 36 | JA (9) | 60S ribosomal protein L35Ae, putative | polymer | 140 | 16306.4 | 1 | UniProt (Q8IHT9) Pfam (PF01247) | Plasmodium falciparum 3D7 | 60S ribosomal protein L35ae,putative |
| 37 | KA (a) | 60S ribosomal protein L34 | polymer | 150 | 17407.0 | 1 | UniProt (Q8IBY4) Pfam (PF01199) | Plasmodium falciparum 3D7 | |
| 38 | LA (b) | 60S ribosomal protein L36 | polymer | 112 | 12825.4 | 1 | UniProt (Q8I713) Pfam (PF01158) | Plasmodium falciparum 3D7 | |
| 39 | MA (c) | Ribosomal protein L37 | polymer | 92 | 10571.6 | 1 | UniProt (C0H4L5) Pfam (PF01907) | Plasmodium falciparum 3D7 | |
| 40 | NA (d) | 60S ribosomal protein L38 | polymer | 87 | 10341.7 | 1 | UniProt (Q8II62) Pfam (PF01781) | Plasmodium falciparum 3D7 | 60S ribosomal protein L38e,putative |
| 41 | OA (e) | 60S ribosomal protein L39 | polymer | 51 | 6540.9 | 1 | UniProt (C0H4H3) Pfam (PF00832) | Plasmodium falciparum 3D7 | |
| 42 | PA (f) | Ubiquitin-60S ribosomal protein L40 | polymer | 128 | 14645.2 | 1 | UniProt (Q8ID50) Pfam (PF00240) Pfam (PF01020) | Plasmodium falciparum 3D7 | |
| 43 | QA (g) | 60S ribosomal protein L41 | polymer | 39 | 5108.3 | 1 | UniProt (C6S3G4) Pfam (PF05162) | Plasmodium falciparum 3D7 | 60S ribosomal protein L41,putative |
| 44 | RA (h) | 60S ribosomal protein L37a | polymer | 96 | 10826.1 | 1 | UniProt (O96184) Pfam (PF01780) | Plasmodium falciparum 3D7 | |
| 45 | SA (i) | 60S ribosomal protein L44 | polymer | 104 | 12194.9 | 1 | UniProt (O97231) Pfam (PF00935) | Plasmodium falciparum 3D7 | |
| 46 | BH, TA (K, A) | (11R,12S)- Mefloquine | non-polymer | 378.3 | 2 | Chemie (YMZ) | |||
| 47 | AB, AC, AD, AE, AF... (A, C, M, B) | MAGNESIUM ION | non-polymer | 24.3 | 164 | Chemie (MG) | |||
| 48 | DH, EH, FH, GH, HH (a, c, f, h, i) | ZINC ION | non-polymer | 65.4 | 5 | Chemie (ZN) |
Sequence modifications
A: 1 - 3788 (GenBank: 1013064538)
B: 1 - 119 (GenBank: 1016052399)
L: 1 - 215 (UniProt: Q8IAX6)
| PDB | External Database | Details |
|---|---|---|
| C 821 | U 1087390 | conflict |
| PDB | External Database | Details |
|---|---|---|
| A 23 | C 779399 | conflict |
| U 24 | C 779400 | conflict |
| G 119 | U 779495 | conflict |
| PDB | External Database | Details |
|---|---|---|
| His 19 | Arg 19 | conflict |
| Arg 20 | His 20 | conflict |
| Cys 201 | Arg 201 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 45 |
| Total formula weight | 2131546.0 | |
| Non-Polymers* | Number of molecules | 171 |
| Total formula weight | 5069.7 | |
| All* | Total formula weight | 2136615.7 |
