2RJK
 
 | | Crystal Structure of Human TL1A Extracellular Domain C95S Mutant | | Descriptor: | TNF superfamily ligand TL1A | | Authors: | Zhan, C, Yan, Q, Patskovsky, Y, Shi, W, Ramagopal, U.A, Toro, R, Bonanno, J, Nathenson, S.G, Almo, S.C. | | Deposit date: | 2007-10-15 | | Release date: | 2008-08-26 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Biochemical and structural characterization of the human TL1A ectodomain.
Biochemistry, 48, 2009
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2RJL
 | | Crystal structure of human TL1A extracellular domain C95S/C135S mutant | | Descriptor: | TNF superfamily ligand TL1A | | Authors: | Zhan, C, Patskovsky, Y, Yan, Q, Shi, W, Toro, R, Bonanno, J, Nathenson, S.G, Almo, S.C. | | Deposit date: | 2007-10-15 | | Release date: | 2008-08-26 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Biochemical and structural characterization of the human TL1A ectodomain.
Biochemistry, 48, 2009
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4J1R
 | | Crystal Structure of GSK3b in complex with inhibitor 15R | | Descriptor: | (2R)-2-(1H-indol-3-ylmethyl)-1,4-dihydropyrido[2,3-b]pyrazin-3(2H)-one, Glycogen synthase kinase-3 beta, PHOSPHATE ION, ... | | Authors: | Zhan, C, Wang, Y, Wach, J, Sheehan, P, Zhong, C, Harris, R, Patskovsky, Y, Bishop, J, Haggarty, S, Ramek, A, Berry, K, O'Herin, C, Koehler, A.N, Hung, A.W, Young, D.W, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC) | | Deposit date: | 2013-02-01 | | Release date: | 2013-03-20 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.702 Å) | | Cite: | Fragment-based approach using diversity-oriented synthesis yields a GSK3b inhibitor
To be Published
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4EN0
 | | Crystal structure of light | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, PHOSPHATE ION, ... | | Authors: | Zhan, C, Liu, W, Patskovsky, Y, Ramagopal, U.A, Bonanno, J.B, Nathenson, S.G, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Atoms-to-Animals: The Immune Function Network (IFN) | | Deposit date: | 2012-04-12 | | Release date: | 2012-05-09 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.59 Å) | | Cite: | Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly.
Structure, 22, 2014
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3MHD
 | | Crystal structure of DCR3 | | Descriptor: | Tumor necrosis factor receptor superfamily member 6B | | Authors: | Zhan, C, Patskovsky, Y, Yan, Q, Li, Z, Ramagopal, U.A, Nathenson, S.G, Almo, S.C. | | Deposit date: | 2010-04-07 | | Release date: | 2011-02-23 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.901 Å) | | Cite: | Decoy Strategies: The Structure of TL1A:DcR3 Complex.
Structure, 19, 2011
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3MI8
 | | The structure of TL1A-DCR3 COMPLEX | | Descriptor: | TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 15, SECRETED FORM, Tumor necrosis factor receptor superfamily member 6B | | Authors: | Zhan, C, Patskovsky, Y, Yan, Q, Li, Z, Ramagopal, U.A, Nathenson, S.G, Almo, S.C. | | Deposit date: | 2010-04-09 | | Release date: | 2011-02-23 | | Last modified: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (2.951 Å) | | Cite: | Decoy Strategies: The Structure of TL1A:DcR3 Complex.
Structure, 19, 2011
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3K51
 | | Crystal Structure of DcR3-TL1A complex | | Descriptor: | Decoy receptor 3, Tumor necrosis factor ligand superfamily member 15, secreted form | | Authors: | Zhan, C, Patskovsky, Y, Yan, Q, Li, Z, Ramagopal, U.A, Nathenson, S.G, Almo, S.C. | | Deposit date: | 2009-10-06 | | Release date: | 2010-10-13 | | Last modified: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Decoy Strategies: The Structure of TL1A:DcR3 Complex.
Structure, 19, 2011
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2QE3
 | | Crystal structure of human tl1a extracellular domain | | Descriptor: | CHLORIDE ION, TNF superfamily ligand TL1A | | Authors: | Zhan, C, Yan, Q, Patskovsky, Y, Shi, W, Toro, R, Bonanno, J, Nathenson, S.G, Almo, S.C. | | Deposit date: | 2007-06-22 | | Release date: | 2007-07-17 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Biochemical and structural characterization of the human TL1A ectodomain.
Biochemistry, 48, 2009
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2HC9
 | | Structure of Caenorhabditis elegans leucine aminopeptidase-zinc complex (LAP1) | | Descriptor: | BICARBONATE ION, GLYCEROL, Leucine aminopeptidase 1, ... | | Authors: | Zhan, C, Patskovsky, Y, Wengerter, B.C, Ramagopal, U, Milstein, S, Vidal, M, Almo, S.C, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) | | Deposit date: | 2006-06-15 | | Release date: | 2006-08-15 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Crystal Structure and Function of Caenorhabditis Elegans Leucine Aminopeptidase
To be Published
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4J71
 | | Crystal Structure of GSK3b in complex with inhibitor 1R | | Descriptor: | (2R)-2-methyl-1,4-dihydropyrido[2,3-b]pyrazin-3(2H)-one, CHLORIDE ION, Glycogen synthase kinase-3 beta, ... | | Authors: | Zhan, C, Wang, Y, Wach, J, Sheehan, P, Zhong, C, Harris, R, Patskovsky, Y, Bishop, J, Haggarty, S, Ramek, A, Berry, K, O'Herin, C, Koehler, A.N, Hung, A.W, Young, D.W, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC) | | Deposit date: | 2013-02-12 | | Release date: | 2013-03-20 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Fragment-based approach using diversity-oriented synthesis yields a GSK3b inhibitor
To be Published
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4NSX
 | | Crystal Structure of the Utp21 tandem WD Domain | | Descriptor: | CITRATE ANION, U3 small nucleolar RNA-associated protein 21 | | Authors: | Zhang, C, Ye, K. | | Deposit date: | 2013-11-29 | | Release date: | 2014-02-19 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structure of Utp21 Tandem WD Domain Provides Insight into the Organization of the UTPB Complex Involved in Ribosome Synthesis
Plos One, 9, 2014
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5GP1
 | | Crystal structure of ZIKV NS5 Methyltransferase in complex with GTP and SAH | | Descriptor: | NICKEL (II) ION, P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, RNA-directed RNA polymerase NS5, ... | | Authors: | Zhang, C, Jin, T. | | Deposit date: | 2016-07-30 | | Release date: | 2016-12-07 | | Last modified: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.444 Å) | | Cite: | Structure of the NS5 methyltransferase from Zika virus and implications in inhibitor design
Biochem. Biophys. Res. Commun., 492, 2017
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7RIK
 | | Magic-Angle-Spinning NMR Structure of Kinesin-1 Motor Domain Assembled with Microtubules | | Descriptor: | Kinesin-1 heavy chain | | Authors: | Zhang, C, Guo, C, Russell, R.W, Quinn, C.M, Li, M, Williams, J.C, Gronenborn, A.M, Polenova, T. | | Deposit date: | 2021-07-20 | | Release date: | 2022-11-23 | | Last modified: | 2024-05-15 | | Method: | SOLID-STATE NMR | | Cite: | Magic-angle-spinning NMR structure of the kinesin-1 motor domain assembled with microtubules reveals the elusive neck linker orientation
Nat Commun, 13, 2022
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4Q65
 | | Structure of the E. coli Peptide Transporter YbgH | | Descriptor: | Dipeptide permease D | | Authors: | Zhang, C, Zhao, Y, Mao, G, Liu, M, Wang, X. | | Deposit date: | 2014-04-21 | | Release date: | 2014-08-13 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Crystal structure of the E. coli peptide transporter YbgH.
Structure, 22, 2014
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7BTA
 | | Crystal structure of Rheb D60K mutant bound to GDP | | Descriptor: | GTP-binding protein Rheb, GUANOSINE-5'-DIPHOSPHATE, PHOSPHATE ION | | Authors: | Zhang, C, Zhang, T, Ding, J. | | Deposit date: | 2020-03-31 | | Release date: | 2020-06-17 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Molecular basis for the functions of dominantly active Y35N and inactive D60K Rheb mutants in mTORC1 signaling.
J Mol Cell Biol, 12, 2020
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7BTD
 | | Crystal structure of Rheb Y35N mutant bound to GppNHp | | Descriptor: | GTP-binding protein Rheb, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | | Authors: | Zhang, C, Zhang, T, Ding, J. | | Deposit date: | 2020-04-01 | | Release date: | 2020-06-17 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Molecular basis for the functions of dominantly active Y35N and inactive D60K Rheb mutants in mTORC1 signaling.
J Mol Cell Biol, 12, 2020
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2DHO
 | | Crystal structure of human IPP isomerase I in space group P212121 | | Descriptor: | CHLORIDE ION, Isopentenyl-diphosphate delta-isomerase 1, MANGANESE (II) ION, ... | | Authors: | Zhang, C, Wei, Z, Gong, W. | | Deposit date: | 2006-03-24 | | Release date: | 2007-06-05 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Crystal structures of human IPP isomerase: new insights into the catalytic mechanism
J.Mol.Biol., 366, 2007
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8W6P
 | | Crystal structure of dimeric murine SMPDL3A | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Acid sphingomyelinase-like phosphodiesterase 3a, ... | | Authors: | Zhang, C, Liu, P, Fan, S, Hou, Y. | | Deposit date: | 2023-08-29 | | Release date: | 2023-12-20 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.91 Å) | | Cite: | SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing.
Immunity, 56, 2023
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8EPB
 | | Engineering Crystals with Tunable Symmetries from 14- or 16-Base-Long DNA Strands | | Descriptor: | DNA (5'-D(*CP*GP*CP*TP*GP*GP*TP*GP*GP*TP*TP*CP*GP*A)-3'), DNA (5'-D(*GP*AP*CP*CP*AP*GP*CP*CP*GP*AP*AP*CP*CP*T)-3') | | Authors: | Zhang, C, Zhao, J, Lu, B, Sha, R, Seeman, N.C, Noinaj, N, Mao, C. | | Deposit date: | 2022-10-05 | | Release date: | 2023-03-08 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.61 Å) | | Cite: | Engineering DNA Crystals toward Studying DNA-Guest Molecule Interactions.
J.Am.Chem.Soc., 145, 2023
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8EPF
 | | Engineering Crystals with Tunable Symmetries from 14- or 16-Base-Long DNA Strands | | Descriptor: | DNA (5'-D(*AP*CP*GP*CP*TP*GP*GP*TP*GP*GP*TP*TP*CP*GP*CP*A)-3'), DNA (5'-D(*GP*TP*AP*CP*CP*AP*GP*CP*CP*GP*AP*AP*CP*CP*TP*G)-3') | | Authors: | Zhang, C, Zhao, J, Lu, B, Sha, R, Seeman, N.C, Noinaj, N, Mao, C. | | Deposit date: | 2022-10-05 | | Release date: | 2023-03-08 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.61 Å) | | Cite: | Engineering DNA Crystals toward Studying DNA-Guest Molecule Interactions.
J.Am.Chem.Soc., 145, 2023
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5IC7
 | | Structure of the WD domain of UTP18 | | Descriptor: | Putative uncharacterized protein, SULFATE ION | | Authors: | Zhang, C, Ye, K. | | Deposit date: | 2016-02-22 | | Release date: | 2016-07-06 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.331 Å) | | Cite: | Integrative structural analysis of the UTPB complex, an early assembly factor for eukaryotic small ribosomal subunits
Nucleic Acids Res., 44, 2016
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5BOA
 | | Crystal Structure of the Meningitis Pathogen Streptococcus suis adhesion Fhb bound to the disaccharide receptor Gb2 | | Descriptor: | Translation initiation factor 2 (IF-2 GTPase), alpha-D-galactopyranose-(1-4)-beta-D-galactopyranose | | Authors: | Zhang, C, Yu, Y, Yang, M, Jiang, Y. | | Deposit date: | 2015-05-27 | | Release date: | 2016-05-04 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.708 Å) | | Cite: | Structural basis of the interaction between the meningitis pathogen Streptococcus suis adhesin Fhb and its human receptor.
Febs Lett., 590, 2016
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7BTC
 | | Crystal structure of Rheb Y35N mutant bound to GDP | | Descriptor: | GTP-binding protein Rheb, GUANOSINE-5'-DIPHOSPHATE | | Authors: | Zhang, C, Zhang, T, Ding, J. | | Deposit date: | 2020-04-01 | | Release date: | 2020-06-17 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.101 Å) | | Cite: | Molecular basis for the functions of dominantly active Y35N and inactive D60K Rheb mutants in mTORC1 signaling.
J Mol Cell Biol, 12, 2020
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7BXX
 | | Tetanus neurotoxin translocation domain -C467S | | Descriptor: | Tetanus toxin | | Authors: | Zhang, C.M, Imoto, Y, Fukuda, Y, Yamashita, E, Inoue, T. | | Deposit date: | 2020-04-21 | | Release date: | 2021-02-17 | | Last modified: | 2023-11-29 | | Method: | SOLUTION SCATTERING (2.34 Å), X-RAY DIFFRACTION | | Cite: | Structural flexibility of the tetanus neurotoxin revealed by crystallographic and solution scattering analyses.
J Struct Biol X, 5, 2021
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7BY4
 | | Tetanus neurotoxin receptor binding domain | | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, SODIUM ION, ... | | Authors: | Zhang, C.M, Imoto, Y, Inoue, T. | | Deposit date: | 2020-04-21 | | Release date: | 2021-02-17 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structural flexibility of the tetanus neurotoxin revealed by crystallographic and solution scattering analyses.
J Struct Biol X, 5, 2021
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