8W6P

Crystal structure of dimeric murine SMPDL3A

Summary for 8W6P

• Entry DOI: 10.2210/pdb8w6p/pdb
• Descriptor: Acid sphingomyelinase-like phosphodiesterase 3a, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• Functional Keywords: innate immunity, lipid metabolism, hydrolase
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 2
• Total formula weight: 97210.11

Authors

Zhang, C.,Liu, P.,Fan, S.,Hou, Y. (deposition date: 2023-08-29, release date: 2023-12-20)

• Primary citation: Hou, Y.,Wang, Z.,Liu, P.,Wei, X.,Zhang, Z.,Fan, S.,Zhang, L.,Han, F.,Song, Y.,Chu, L.,Zhang, C.; SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing.; Immunity, 56:2492-2507.e10, 2023; PubMed: 37890481; DOI: 10.1016/j.immuni.2023.10.001

Experimental method

X-RAY DIFFRACTION (1.91 Å)