5FNV
 
 | | a new complex structure of tubulin with an alpha-beta unsaturated lactone | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Wang, Y, Naismith, J, Zhu, X. | | 登録日 | 2015-11-16 | | 公開日 | 2016-05-18 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | | 主引用文献 | Pironetin Reacts Covalently with Cysteine-316 of Alpha-Tubulin to Destabilize Microtubule.
Nat.Commun., 7, 2016
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4ESP
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7DET
 | | Crystal structure of SARS-CoV-2 RBD in complex with a neutralizing antibody scFv | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, antibody scFv | | 著者 | Wang, Y, Zhang, G, Li, X, Rao, Z, Guo, Y. | | 登録日 | 2020-11-05 | | 公開日 | 2021-03-31 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes.
Plos Biol., 19, 2021
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2JOW
 | | Differences in the electrostatic surfaces of the type III secretion needle proteins | | 分子名称: | Protein prgI | | 著者 | Wang, Y, Ouellette, A.N, Egan, C.W, De Guzman, R.N. | | 登録日 | 2007-04-06 | | 公開日 | 2007-07-24 | | 最終更新日 | 2024-05-08 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Differences in the Electrostatic Surfaces of the Type III Secretion Needle Proteins PrgI, BsaL, and MxiH
J.Mol.Biol., 371, 2007
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5GSW
 | | Crystal structure of EV71 3C in complex with N69S 1.8k | | 分子名称: | 3C protein, ~{N}-[(2~{S})-3-(4-fluorophenyl)-1-oxidanylidene-1-[[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepiperidin-3-yl]propan-2-yl]amino]propan-2-yl]-5-methyl-1,2-oxazole-3-carboxamide | | 著者 | Wang, Y. | | 登録日 | 2016-08-17 | | 公開日 | 2017-05-31 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (3.19 Å) | | 主引用文献 | Structure of the Enterovirus 71 3C Protease in Complex with NK-1.8k and Indications for the Development of Antienterovirus Protease Inhibitor
Antimicrob. Agents Chemother., 61, 2017
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5GSO
 | | Crystal Structures of EV71 3C Protease in complex with NK-1.8k | | 分子名称: | 3C protein, ~{N}-[(2~{S})-3-(4-fluorophenyl)-1-oxidanylidene-1-[[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepiperidin-3-yl]propan-2-yl]amino]propan-2-yl]-5-methyl-1,2-oxazole-3-carboxamide | | 著者 | Wang, Y. | | 登録日 | 2016-08-16 | | 公開日 | 2017-05-31 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structure of the Enterovirus 71 3C Protease in Complex with NK-1.8k and Indications for the Development of Antienterovirus Protease Inhibitor
Antimicrob. Agents Chemother., 61, 2017
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3LJQ
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6DFX
 | | human diabetogenic TCR T1D3 in complex with DQ8-p8E9E peptide | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Wang, Y, Dai, S. | | 登録日 | 2018-05-15 | | 公開日 | 2019-04-17 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | | 主引用文献 | How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes.
Sci Immunol, 4, 2019
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6DFQ
 | | mouse diabetogenic TCR I.29 | | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, TCR alpha chain, ... | | 著者 | Wang, Y, Dai, S. | | 登録日 | 2018-05-15 | | 公開日 | 2019-04-17 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes.
Sci Immunol, 4, 2019
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6DFV
 | | Mouse diabetogenic TCR 8F10 | | 分子名称: | 1,2-ETHANEDIOL, TCR alpha chain, TCR beta chain | | 著者 | Wang, Y, Dai, S. | | 登録日 | 2018-05-15 | | 公開日 | 2019-04-17 | | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | | 主引用文献 | How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes.
Sci Immunol, 4, 2019
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6DFW
 | | TCR 8F10 in complex with IAg7-p8G9E | | 分子名称: | 8F10 alpha chain, 8F10 beta chain, H-2 class II histocompatibility antigen, ... | | 著者 | Wang, Y, Dai, S. | | 登録日 | 2018-05-15 | | 公開日 | 2019-04-17 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes.
Sci Immunol, 4, 2019
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6CCY
 | | Crystal structure of Akt1 in complex with a selective inhibitor | | 分子名称: | (5R)-4-(4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[2-(pyrrolidin-1-yl)ethyl]-1H-imidazol-2-yl}piperidin-1-yl)-5-methyl-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one, RAC-alpha serine/threonine-protein kinase,PIFtide | | 著者 | Wang, Y, Stout, S. | | 登録日 | 2018-02-07 | | 公開日 | 2018-05-02 | | 最終更新日 | 2018-05-16 | | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | | 主引用文献 | Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKT.
Bioorg. Med. Chem. Lett., 28, 2018
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3K62
 | | Crystal structure of FBF-2/gld-1 FBEb complex | | 分子名称: | 5'-R(*UP*GP*UP*GP*UP*UP*AP*UP*C)-3', Fem-3 mRNA-binding factor 2 | | 著者 | Wang, Y, Opperman, L, Wickens, M, Hall, T.M.T. | | 登録日 | 2009-10-08 | | 公開日 | 2009-11-03 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural basis for specific recognition of multiple mRNA targets by a PUF regulatory protein.
Proc.Natl.Acad.Sci.USA, 106, 2009
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3K64
 | | Crystal structure of FBF-2/fem-3 PME complex | | 分子名称: | 5'-R(*UP*GP*UP*GP*UP*CP*AP*UP*U)-3', Fem-3 mRNA-binding factor 2 | | 著者 | Wang, Y, Opperman, L, Wickens, M, Hall, T.M.T. | | 登録日 | 2009-10-08 | | 公開日 | 2009-11-03 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural basis for specific recognition of multiple mRNA targets by a PUF regulatory protein.
Proc.Natl.Acad.Sci.USA, 106, 2009
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6BLR
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3K5Q
 | | Crystal structure of FBF-2/FBE complex | | 分子名称: | 5'-R(P*UP*GP*UP*AP*CP*UP*AP*UP*A)-3', Fem-3 mRNA-binding factor 2 | | 著者 | Wang, Y, Opperman, L, Wickens, M, Hall, T.M.T. | | 登録日 | 2009-10-07 | | 公開日 | 2009-11-03 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural basis for specific recognition of multiple mRNA targets by a PUF regulatory protein.
Proc.Natl.Acad.Sci.USA, 106, 2009
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3K5Z
 | | Crystal structure of FBF-2/gld-1 FBEa G4A mutant complex | | 分子名称: | 5'-R(*UP*GP*UP*AP*CP*CP*AP*UP*A)-3', Fem-3 mRNA-binding factor 2 | | 著者 | Wang, Y, Opperman, L, Wickens, M, Hall, T.M.T. | | 登録日 | 2009-10-08 | | 公開日 | 2009-11-03 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis for specific recognition of multiple mRNA targets by a PUF regulatory protein.
Proc.Natl.Acad.Sci.USA, 106, 2009
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6DFS
 | | mouse TCR I.29 in complex with IAg7-p8E9E6ss | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, H-2 class II histocompatibility antigen, A-D alpha chain, ... | | 著者 | Wang, Y, Dai, S. | | 登録日 | 2018-05-15 | | 公開日 | 2019-04-17 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes.
Sci Immunol, 4, 2019
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4P6G
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4P6E
 | | Crystal Structure of Human Cathepsin S Bound to a Non-covalent Inhibitor | | 分子名称: | Cathepsin S, N-[(8R)-8-(benzoylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]-4-methylpiperazine-1-carboxamide, SULFATE ION | | 著者 | Wang, Y, Jadhav, P.K, Deng, G.G. | | 登録日 | 2014-03-24 | | 公開日 | 2014-10-29 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Discovery of Cathepsin S Inhibitor LY3000328 for the Treatment of Abdominal Aortic Aneurysm.
Acs Med.Chem.Lett., 5, 2014
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5DMK
 | | Crystal Structure of IAg7 in complex with RLGL-WE14 | | 分子名称: | CITRATE ANION, H-2 class II histocompatibility antigen, A-D alpha chain, ... | | 著者 | Wang, Y, Jin, N, Dai, S, Kappler, J.W. | | 登録日 | 2015-09-08 | | 公開日 | 2015-10-28 | | 最終更新日 | 2016-04-06 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | N-terminal additions to the WE14 peptide of chromogranin A create strong autoantigen agonists in type 1 diabetes.
Proc.Natl.Acad.Sci.USA, 112, 2015
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5H74
 | | Crystal structure of T2R-TTL-14b complex | | 分子名称: | (2~{S},4~{R})-4-[[2-[(1~{R},3~{R})-1-acetyloxy-3-[hexyl-[(2~{S},3~{S})-3-methyl-2-[[(2~{R})-1-methylpiperidin-2-yl]carbonylamino]pentanoyl]amino]-4-methyl-pentyl]-1,3-thiazol-4-yl]carbonylamino]-5-(4-fluorophenyl)-2-methyl-pentanoic acid, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | | 著者 | Wang, Y, Yu, Y, Chen, Q, Yang, J. | | 登録日 | 2016-11-17 | | 公開日 | 2017-11-22 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structure-Activity Relationship Studies of Tubulysin Analogues: Anticancer N-Alkyltubulysins with Subpicomolar Activity and the Crystal Structure Binding to Tubulin
To Be Published
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8X1V
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5XG8
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7F9Y
 | | ghrelin-bound ghrelin receptor in complex with Gq | | 分子名称: | CHOLESTEROL, Engineered G-alpha-q subunit, Ghrelin-28, ... | | 著者 | Wang, Y, Zhuang, Y, Xu, P, Xu, H.E, Jiang, Y. | | 登録日 | 2021-07-05 | | 公開日 | 2021-08-18 | | 最終更新日 | 2022-03-16 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor.
Nat Commun, 12, 2021
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