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6DFX

human diabetogenic TCR T1D3 in complex with DQ8-p8E9E peptide

Summary for 6DFX
Entry DOI10.2210/pdb6dfx/pdb
Related6DFS
DescriptorMHC class II HLA-DQ-alpha chain, MHC class II antigen, T1D3 alpha chain, ... (8 entities in total)
Functional Keywordst cell receptor, type 1 diabetes, autoimmunity, immune system
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains8
Total formula weight193195.87
Authors
Wang, Y.,Dai, S. (deposition date: 2018-05-15, release date: 2019-04-17, Last modification date: 2020-07-29)
Primary citationWang, Y.,Sosinowski, T.,Novikov, A.,Crawford, F.,White, J.,Jin, N.,Liu, Z.,Zou, J.,Neau, D.,Davidson, H.W.,Nakayama, M.,Kwok, W.W.,Gapin, L.,Marrack, P.,Kappler, J.W.,Dai, S.
How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes.
Sci Immunol, 4:-, 2019
Cited by
PubMed: 30952805
DOI: 10.1126/sciimmunol.aav7517
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.03 Å)
Structure validation

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