6DFX
human diabetogenic TCR T1D3 in complex with DQ8-p8E9E peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, D) | MHC class II HLA-DQ-alpha chain | polymer | 188 | 21373.9 | 2 | UniProt (Q30069) Pfam (PF00993) Pfam (PF07654) | Homo sapiens (Human) | |
| 2 | B, D (B, E) | MHC class II antigen | polymer | 221 | 25119.2 | 2 | UniProt (U3PYM0) Pfam (PF00969) Pfam (PF07654) | Homo sapiens (Human) | |
| 3 | E, G (G, I) | T1D3 alpha chain | polymer | 207 | 22907.2 | 2 | Homo sapiens (Human) | ||
| 4 | F, H (H, J) | T1D3 beta chain | polymer | 238 | 26843.7 | 2 | Homo sapiens (Human) | ||
| 5 | I (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 6 | J (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 7 | K (D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 8 | L, M, N, O, P... (A, B, D, E, G...) | water | water | 18.0 | 775 | Chemie (HOH) |
Sequence modifications
A, D: 1 - 181 (UniProt: Q30069)
B, E: 3 - 191 (UniProt: U3PYM0)
| PDB | External Database | Details |
|---|---|---|
| Cys 72 | Ile 75 | conflict |
| Gly 182 | - | expression tag |
| Gly 183 | - | expression tag |
| Leu 184 | - | expression tag |
| Val 185 | - | expression tag |
| Pro 186 | - | expression tag |
| Arg 187 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Val -27 | - | expression tag |
| Glu -26 | - | expression tag |
| Glu -25 | - | expression tag |
| Leu -24 | - | expression tag |
| Tyr -23 | - | expression tag |
| Leu -22 | - | expression tag |
| Val -21 | - | expression tag |
| Ala -20 | - | expression tag |
| Gly -19 | - | expression tag |
| Glu -18 | - | expression tag |
| Glu -17 | - | expression tag |
| Gly -16 | - | expression tag |
| Cys -15 | - | expression tag |
| Gly -14 | - | expression tag |
| Gly -13 | - | expression tag |
| Gly -12 | - | expression tag |
| Gly -11 | - | expression tag |
| Ser -10 | - | expression tag |
| Leu -9 | - | expression tag |
| Val -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Gly 1 | - | expression tag |
| Gly 2 | - | expression tag |
| Gly 192 | - | expression tag |
| Gly 193 | - | expression tag |
| Leu 194 | - | expression tag |
| Val 195 | - | expression tag |
| Pro 196 | - | expression tag |
| Arg 197 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 192488.2 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 283.3 | |
| All* | Total formula weight | 193195.9 |
