4ESP
Crystal Structure of Peanut Allergen Ara h 5
Summary for 4ESP
| Entry DOI | 10.2210/pdb4esp/pdb |
| Descriptor | Profilin, 1,2-ETHANEDIOL, ISOPROPYL ALCOHOL, ... (4 entities in total) |
| Functional Keywords | peanut allergen, allergy, ara h 5, profilin, allergen |
| Biological source | Arachis hypogaea (goober,ground-nut) |
| Total number of polymer chains | 1 |
| Total formula weight | 14600.55 |
| Authors | Wang, Y.,Zhang, Y.Z. (deposition date: 2012-04-23, release date: 2013-03-06, Last modification date: 2024-02-28) |
| Primary citation | Wang, Y.,Fu, T.J.,Howard, A.,Kothary, M.H.,McHugh, T.H.,Zhang, Y. Crystal Structure of Peanut ( Arachis hypogaea ) Allergen Ara h 5. J.Agric.Food Chem., 61:1573-1578, 2013 Cited by PubMed Abstract: Profilins from numerous species are known to be allergens, including food allergens, such as peanut ( Arachis hypogaea ) allergen Ara h 5, and pollen allergens, such as birch allergen Bet v 2. Patients with pollen allergy can also cross-react to peanut. Structural characterization of allergens will allow a better understanding of the allergenicity of food allergens and their cross-reactivities. The three-dimensional structures of most known food allergens remain to be elucidated. Here, we report the first crystallographic study of a food allergen in the profilin family. The structure of peanut allergen Ara h 5 was determined, and the resolution of the final refined structure was 1.1 Å. Structure alignment revealed that Ara h 5 is more similar to Bet v 2 than to Hev b 8, although sequence alignment suggested that Ara h 5 is more closely related to Hev b 8 than to Bet v 2, indicating that homology-model-based prediction of immunoglobulin E epitopes needs to be interpreted with caution. PubMed: 23350842DOI: 10.1021/jf303861p PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.1 Å) |
Structure validation
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