8X1V

NMR structure of a bimolecular parallel G-quadruplex formed by AAGGG repeats from pathogenic RFC1 gene

Summary for 8X1V

• Entry DOI: 10.2210/pdb8x1v/pdb
• Descriptor: DNA (5'-D(*AP*AP*GP*GP*GP*AP*AP*GP*GP*GP*AP*A)-3') (1 entity in total)
• Functional Keywords: dna, g-quadruplex, aaggg repeats, rfc1 gene
• Biological source: Homo sapiens
• Total number of polymer chains: 2
• Total formula weight: 7619.04

Authors

Wang, Y.,Guo, P.,Han, D. (deposition date: 2023-11-08, release date: 2024-01-17, Last modification date: 2024-04-03)

• Primary citation: Wang, Y.,Wang, J.,Yan, Z.,Hou, J.,Wan, L.,Yang, Y.,Liu, Y.,Yi, J.,Guo, P.,Han, D.; Structural investigation of pathogenic RFC1 AAGGG pentanucleotide repeats reveals a role of G-quadruplex in dysregulated gene expression in CANVAS.; Nucleic Acids Res., 52:2698-2710, 2024; PubMed: 38266156; DOI: 10.1093/nar/gkae032

Experimental method

SOLUTION NMR