5FNV

a new complex structure of tubulin with an alpha-beta unsaturated lactone

Summary for 5FNV

Entry DOI	10.2210/pdb5fnv/pdb
Descriptor	TUBULIN ALPHA-1B CHAIN, PIRONETIN, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
Functional Keywords	structural protein, tubulin complex alpha-beta unsaturated lactone
Biological source	GALLUS GALLUS (CHICKEN) More
Cellular location	Cytoplasm, cytoskeleton: Q2XVP4 P02554 Golgi apparatus : P63043
Total number of polymer chains	6
Total formula weight	264899.44
Authors	Wang, Y.,Naismith, J.,Zhu, X. (deposition date: 2015-11-16, release date: 2016-05-18, Last modification date: 2024-01-10)
Primary citation	Yang, J.,Wang, Y.,Wang, T.,Jiang, J.,Botting, C.H.,Liu, H.,Chen, Q.,Yang, J.,Naismith, J.H.,Zhu, X.,Chen, L. Pironetin Reacts Covalently with Cysteine-316 of Alpha-Tubulin to Destabilize Microtubule. Nat.Commun., 7:12103-, 2016 Cited by PubMed: 27357539 DOI: 10.1038/NCOMMS12103 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.61 Å)

Structure validation