5FNV
a new complex structure of tubulin with an alpha-beta unsaturated lactone
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | TUBULIN ALPHA-1B CHAIN | polymer | 451 | 50204.4 | 2 | UniProt (Q2XVP4) Pfam (PF00091) Pfam (PF03953) | GALLUS GALLUS (CHICKEN) | ALPHA-TUBULIN UBIQUITOUS, TUBULIN K-ALPHA-1, TUBULIN ALPHA- UBIQUITOUS CHAIN, TUBULIN ALPHA SUBUNIT |
| 2 | B, D (B, D) | TUBULIN BETA CHAIN | polymer | 445 | 49907.8 | 2 | UniProt (P02554) Pfam (PF00091) Pfam (PF03953) | RATTUS NORVEGICUS (NORWAY RAT) | BETA-TUBULIN, TUBULIN BETA SUBUNIT |
| 3 | E (E) | STATHMIN-4 | polymer | 143 | 16844.2 | 1 | UniProt (P63043) Pfam (PF00836) | SUS SCROFA (PIG) | STATHMIN-LIKE PROTEIN B3, RB3, ISTATHMIN-4 |
| 4 | F (F) | TUBULIN TYROSINE LIGASE | polymer | 384 | 44378.5 | 1 | UniProt (E1BQ43) | SUS SCROFA (PIG) | |
| 5 | G, O, S (A, C, D) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 3 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 6 | H, K, P, T (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) PubChem (888) | |||
| 7 | I, L, Q (A, B, C) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) PubChem (271) | |||
| 8 | J (B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) | |||
| 9 | M, N (B) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 2 | Chemie (MES) PubChem (4478249) | |||
| 10 | R (C) | PIRONETIN | non-polymer | 326.5 | 1 | Chemie (X3H) PubChem (101054774) PubChem (163076590) | |||
| 11 | U (F) | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | non-polymer | 505.2 | 1 | Chemie (ACP) PubChem (4799) PubChem (46936826) PubChem (91532) PubChem (91885473) PubChem (157749842) PubChem (134943439) PubChem (157749839) | |||
| 12 | V, W, X, Y, Z (A, B, C, D, F) | water | water | 18.0 | 68 | Chemie (HOH) |
Sequence modifications
E: 5 - 145 (UniProt: P63043)
F: 1 - 378 (UniProt: E1BQ43)
| PDB | External Database | Details |
|---|---|---|
| Met 3 | - | expression tag |
| Ala 4 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| His 379 | - | expression tag |
| His 380 | - | expression tag |
| His 381 | - | expression tag |
| His 382 | - | expression tag |
| His 383 | - | expression tag |
| His 384 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 261447.1 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 3452.3 | |
| All* | Total formula weight | 264899.4 |
