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6CCY

Crystal structure of Akt1 in complex with a selective inhibitor

Summary for 6CCY
Entry DOI10.2210/pdb6ccy/pdb
DescriptorRAC-alpha serine/threonine-protein kinase,PIFtide, (5R)-4-(4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[2-(pyrrolidin-1-yl)ethyl]-1H-imidazol-2-yl}piperidin-1-yl)-5-methyl-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one (3 entities in total)
Functional Keywordskinase inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor
Biological sourceHomo sapiens (Human)
More
Cellular locationCytoplasm : Q16513
Total number of polymer chains1
Total formula weight40530.12
Authors
Wang, Y.,Stout, S. (deposition date: 2018-02-07, release date: 2018-05-02, Last modification date: 2018-05-16)
Primary citationParthasarathy, S.,Henry, K.,Pei, H.,Clayton, J.,Rempala, M.,Johns, D.,De Frutos, O.,Garcia, P.,Mateos, C.,Pleite, S.,Wang, Y.,Stout, S.,Condon, B.,Ashok, S.,Lu, Z.,Ehlhardt, W.,Raub, T.,Lai, M.,Geeganage, S.,Burkholder, T.P.
Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKT.
Bioorg. Med. Chem. Lett., 28:1887-1891, 2018
Cited by
PubMed: 29655979
DOI: 10.1016/j.bmcl.2018.03.092
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.18 Å)
Structure validation

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